Highly Catalytic Nanodots with Renal Clearance for Radiation Protection
文献类型：期刊论文
| 作者 | Deng, Dehui6; Zhang, Xiao-Dong1; Zhang, Jinxuan2; Wang, Junying3,4; Yang, Jiang5; Chen, Jie3,4; Shen, Xiu3,4; Deng, Jiao6; Long, Wei3,4; Sun, Yuan-Ming3,4 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 10期号:4页码:4511-4519 |
| 关键词 | Radiation Radioprotectants Mos2 Dots |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.6b00321 |
| 文献子类 | Article |
| 英文摘要 | Ionizing radiation (gamma and X-ray) is widely used in industry and medicine, but it can also pose a significant hazardous effect on health and induce cancer, physical deformity, and even death, due to DNA damage and invasion of free radicals. There is therefore an urgent unmet demand in designing highly efficient radioprotectants with synergetic integration of effective renal clearance and low toxicity. In this study, we designed ultrasmall (sub-5 mn) highly catalytically active and cysteine-protected MoS2 dots as radioprotectants and investigated their application in protection against ionizing radiation. In vivo preclinical studies showed that the surviving fraction of MoS2-treated mice can appreciably increase to up to 79% when they were exposed to high-energy ionizing radiation. Furthermore, MoS2 dots can contribute in cleaning up the accumulated free radicals within the body, repairing DNA damage, and recovering all vital chemical and biochemical indicators, suggesting their unique role as free radical scavengers. MoS2 dots showed rapid and efficient urinary excretion with more than 80% injected dose eliminated from the body after 24 h due to their ultrasmall hydrodynamic size and did not cause any noticeable toxic responses up to 30 days. |
| WOS关键词 | GUIDED PHOTOTHERMAL THERAPY ; CERIUM OXIDE NANOPARTICLES ; WALLED CARBON NANOTUBES ; IONIZING-RADIATION ; DRUG-DELIVERY ; NUCLEAR-POWER ; GOLD NANOPARTICLES ; CELLULAR-DAMAGE ; CANCER ; MOS2 |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000375245000070 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170864]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhang, Xiao-Dong; Li, Meixian |
| 作者单位 | 1.Tianjin Univ, Dept Phys, Sch Sci, Tianjin 300354, Peoples R China 2.Peking Univ, Inst Analyt Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 3.Chinese Acad Med Sci, Tianjin Key Lab Mol Nucl Med, Inst Radiat Med, 238 Baidi Rd, Tianjin 300192, Peoples R China 4.Peking Union Med Coll, 238 Baidi Rd, Tianjin 300192, Peoples R China 5.Fudan Univ, Dept Environm Sci & Engn, Environm Energy & Nat Resources Ctr, 220 Handan Rd, Shanghai 200433, Peoples R China 6.Chinese Acad Sci, Dalian Inst Chem Phys, iChEM, State Key Lab Catalysis, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Dehui,Zhang, Xiao-Dong,Zhang, Jinxuan,et al. Highly Catalytic Nanodots with Renal Clearance for Radiation Protection[J]. ACS NANO,2016,10(4):4511-4519. |
| APA | Deng, Dehui.,Zhang, Xiao-Dong.,Zhang, Jinxuan.,Wang, Junying.,Yang, Jiang.,...&Li, Meixian.(2016).Highly Catalytic Nanodots with Renal Clearance for Radiation Protection.ACS NANO,10(4),4511-4519. |
| MLA | Deng, Dehui,et al."Highly Catalytic Nanodots with Renal Clearance for Radiation Protection".ACS NANO 10.4(2016):4511-4519. |
入库方式： OAI收割
来源：大连化学物理研究所
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