Biomimetic tumor-induced angiogenesis and anti-angiogenic therapy in a microfluidic model
文献类型：期刊论文
| 作者 | Liu, Lilu2; Xie, Zhaorong2; Zhang, Wenyuan2; Fang, Shimeng2; Kong, Jing2; Jin, Dong2; Li, Jiao2; Li, Xiaojie2; Yang, Xuesong3; Luo, Yong1 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:42页码:35248-35256 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c6ra05645h |
| 文献子类 | Article |
| 英文摘要 | We developed a biomimetic microfluidic model to reproduce hallmark events of tumor-induced angiogenesis. The angiogenic capabilities of salivary gland adenoid cystic carcinoma (ACC) cells and oral squamous cell carcinoma (SCC) cells were assessed in this model. The traditional nude mouse xenograft model was used to investigate the physiological similarity of the microfluidic model to animal models, and the results showed that the angiogenic potential of ACC and SCC cells assessed by the microfluidic model was in agreement with the results obtained from the nude mouse model. The microfluidic model was subsequently used to evaluate the effect of antiangiogenic drugs on ACC- and SCC-induced angiogenesis. The antiangiogenic effect of anti-VEGF was further compared between the microfluidic and nude mouse models, and showed that it effectively inhibited tumor-induced angiogenesis in both the microfluidic model and the nude mouse model. Thus, tumor-induced angiogenesis reproduced in the microfluidic model may expand the capabilities of cell culture models, providing a low-cost, timesaving, and rapid alternative to animal models. |
| WOS关键词 | ENDOTHELIAL GROWTH-FACTOR ; CELL-INTERACTIONS ; IN-VITRO ; CANCER ; EXPRESSION ; MORPHOGENESIS ; COCULTURE ; PHOSPHORYLATION ; ANGIOPOIETIN-2 ; MICROVESSELS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000374349600013 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170866]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Liu, Tingjiao |
| 作者单位 | 1.Dalian Univ Technol, Fac Chem Environm & Biol Sci & Technol, 2 Linggong Rd, Dalian 116024, Peoples R China 2.Dalian Med Univ, Coll Stomatol, Sect Oral Pathol, West Sect 9,South Rd Lvshun, Dalian 116044, Peoples R China 3.Dalian Med Univ, Liaoning Prov Core Lab Glycobiol & Glycoengn, Dept Biochem & Mol Biol, Dalian, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, 457 Zhongshan Rd, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Lilu,Xie, Zhaorong,Zhang, Wenyuan,et al. Biomimetic tumor-induced angiogenesis and anti-angiogenic therapy in a microfluidic model[J]. RSC ADVANCES,2016,6(42):35248-35256. |
| APA | Liu, Lilu.,Xie, Zhaorong.,Zhang, Wenyuan.,Fang, Shimeng.,Kong, Jing.,...&Liu, Tingjiao.(2016).Biomimetic tumor-induced angiogenesis and anti-angiogenic therapy in a microfluidic model.RSC ADVANCES,6(42),35248-35256. |
| MLA | Liu, Lilu,et al."Biomimetic tumor-induced angiogenesis and anti-angiogenic therapy in a microfluidic model".RSC ADVANCES 6.42(2016):35248-35256. |
入库方式： OAI收割
来源：大连化学物理研究所
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