A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process
文献类型：期刊论文
| 作者 | An, Fan2,3; Qu, Yueyang2,3; Luo, Yong2,3; Fang, Ning1; Liu, Yang2,3; Gao, Zhigang2,3; Zhao, Weijie2,3; Lin, Bingcheng4 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-04-28 |
| 卷号 | 6 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep25022 |
| 文献子类 | Article |
| 英文摘要 | New techniques are urgently needed to replace conventional long and costly pre-clinical testing in the new drug administration process. In this study, a laminated microfluidic device was fabricated to mimic the drug ADME response test in vivo. This proposed device was loaded and cultured with functional cells for drug response investigation and organ tissues that are involved in ADME testing. The drug was introduced from the top of the device and first absorbed by the Caco-2 cell layer, and then metabolized by the primary hepatocyte layer. It subsequently interacted with the MCF-7 cell layer, distributed in the lung, heart and fat tissues, and was finally eliminated through the dialysis membrane. Throughout this on-chip ADME process, the proposed device can be used as a reliable tool to simultaneously evaluate the drug anti-tumor activity, hepatotoxicity and pharmacokinetics. Furthermore, this device was proven to be able to reflect the hepatic metabolism of a drug, drug distribution in the target tissues, and the administration method of a drug. Furthermore, this microdevice is expected to reduce the number of drug candidates and accelerate the pre-clinical testing process subject to animal testing upon adaptation in new drug discovery. |
| WOS关键词 | CHIP ; PHARMACOKINETICS ; SYSTEMS ; HUMANS ; MODEL ; RAT |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000374958700001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170870]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Liu, Yang; Lin, Bingcheng |
| 作者单位 | 1.Georgia State Univ, Dept Chem, Atlanta, GA 30302 USA 2.Dalian Univ Technol, Dept Chem Engn, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China 3.Dalian Univ Technol, Sch Pharmaceut Sci & Technol, 2 Linggong Rd, Dalian 116024, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | An, Fan,Qu, Yueyang,Luo, Yong,et al. A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | An, Fan.,Qu, Yueyang.,Luo, Yong.,Fang, Ning.,Liu, Yang.,...&Lin, Bingcheng.(2016).A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process.SCIENTIFIC REPORTS,6. |
| MLA | An, Fan,et al."A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：大连化学物理研究所
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