Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling
文献类型：期刊论文
| 作者 | Gao, Peng1,6; Yang, Chunzhang2,7; Nesvick, Cody L.2; Feldman, Michael J.2; Sizdahkhani, Saman2; Liu, Huailei3; Chu, Huiying4; Yang, Fengxu1,2,5; Tang, Ling1; Tian, Jing5 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2016-03-22 |
| 卷号 | 7期号:12页码:15200-15214 |
| 关键词 | Hypoxia Hypoxia-inducible Factors Hypotaurine Metabolomics Glioma |
| ISSN号 | 1949-2553 |
| 文献子类 | Article |
| 英文摘要 | Metabolomics has shown significant potential in identifying small molecules specific to tumor phenotypes. In this study we analyzed resected tissue metabolites using capillary electrophoresis-mass spectrometry and found that tissue hypotaurine levels strongly and positively correlated with glioma grade. In vitro studies were conducted to show that hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion. In contrast, taurine, the oxidation metabolite of hypotaurine, decreased intracellular hypotaurine and resulted in glioma cell growth arrest. Lastly, a glioblastoma xenograft mice model was supplemented with taurine feed and exhibited impaired tumor growth. Taken together, these findings suggest that hypotaurine is an aberrantly produced oncometabolite, mediating tumor molecular pathophysiology and progression. The hypotaurine metabolic pathway may provide a potentially new target for glioblastoma diagnosis and therapy. |
| WOS关键词 | MOLECULAR-DYNAMICS SIMULATIONS ; MAGNETIC-RESONANCE-SPECTROSCOPY ; STEM-CELLS ; IN-VITRO ; H-1-NMR SPECTROSCOPY ; METABOLIC PROFILES ; INDUCIBLE FACTORS ; TAURINE LEVELS ; GLIOBLASTOMA ; CANCER |
| WOS研究方向 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000375687200141 |
| 出版者 | IMPACT JOURNALS LLC |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/170962]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhao, Shiguang; Li, Guohui; Zhuang, Zhengping; Xu, Guowang |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 2.NINDS, Surg Neurol Branch, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA 3.Harbin Med Univ, Affiliated Hosp 1, Dept Neurosurg, Harbin, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Lab Mol Modeling & Design, Dalian, Peoples R China 5.Dalian Polytech Univ, Sch Bioengn, Dalian, Peoples R China 6.Dalian Sixth Peoples Hosp, Clin Lab, Dalian, Peoples R China 7.NCI, Neurooncol Branch, NIH, Bethesda, MD 20892 USA |
| 推荐引用方式 GB/T 7714 | Gao, Peng,Yang, Chunzhang,Nesvick, Cody L.,et al. Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling[J]. ONCOTARGET,2016,7(12):15200-15214. |
| APA | Gao, Peng.,Yang, Chunzhang.,Nesvick, Cody L..,Feldman, Michael J..,Sizdahkhani, Saman.,...&Xu, Guowang.(2016).Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling.ONCOTARGET,7(12),15200-15214. |
| MLA | Gao, Peng,et al."Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling".ONCOTARGET 7.12(2016):15200-15214. |
入库方式： OAI收割
来源：大连化学物理研究所
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