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Enantioselective Copper-Catalyzed Formal [4+2] Cycloaddition of o-Aminophenol Derivatives with Propargylic Esters for Synthesis of Optically Active 3,4-Dihydro-2H-1,4-benzoxazines

文献类型：期刊论文

作者Liu, Zhen-Ting1,2; Wang, Ya-Hui1; Zhu, Fu-Lin1,2; Hu, Xiang-Ping1
刊名ORGANIC LETTERS
出版日期2016-03-04
卷号18期号:5页码:1190-1193
ISSN号1523-7060
DOI10.1021/acs.orglett.6b00322
文献子类Article
英文摘要The first copper-catalyzed asymmetric formal [4 + 2] cycloaddition of o-aminophenol derivatives with propargylic esters as the bis-electrophilic C2 synthons for the stereoselective construction of chiral 2,3,4-trisubstituted 2H-1,4-benzoxazines bearing an exocyclic double bond has been developed. By using a structurally modified chiral ketimine P,N,N-ligand, a wide range of optically active 2H-1,4-benzoxazines were prepared in high yields and with excellent enantioselectivities (up to 97% ee).
WOS关键词ASYMMETRIC HYDROGENATION ; SUBSTITUTION-REACTIONS ; 3-SUBSTITUTED 2H-1,4-BENZOXAZINES ; BETA-KETOESTERS ; AMINATION ; ACETATES ; AMINES ; ACID ; ALKYLATION ; COMPLEXES
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000371754000077
源URL[http://cas-ir.dicp.ac.cn/handle/321008/171082]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Hu, Xiang-Ping
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Zhen-Ting,Wang, Ya-Hui,Zhu, Fu-Lin,et al. Enantioselective Copper-Catalyzed Formal [4+2] Cycloaddition of o-Aminophenol Derivatives with Propargylic Esters for Synthesis of Optically Active 3,4-Dihydro-2H-1,4-benzoxazines[J]. ORGANIC LETTERS,2016,18(5):1190-1193.
APA Liu, Zhen-Ting,Wang, Ya-Hui,Zhu, Fu-Lin,&Hu, Xiang-Ping.(2016).Enantioselective Copper-Catalyzed Formal [4+2] Cycloaddition of o-Aminophenol Derivatives with Propargylic Esters for Synthesis of Optically Active 3,4-Dihydro-2H-1,4-benzoxazines.ORGANIC LETTERS,18(5),1190-1193.
MLA Liu, Zhen-Ting,et al."Enantioselective Copper-Catalyzed Formal [4+2] Cycloaddition of o-Aminophenol Derivatives with Propargylic Esters for Synthesis of Optically Active 3,4-Dihydro-2H-1,4-benzoxazines".ORGANIC LETTERS 18.5(2016):1190-1193.

入库方式： OAI收割

来源：大连化学物理研究所

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