Carcinoma-Associated Fibroblasts Lead the Invasion of Salivary Gland Adenoid Cystic Carcinoma Cells by Creating an Invasive Track
文献类型：期刊论文
| 作者 | Li, Jiao2; Jia, Zhuqiang3; Kong, Jing2; Zhang, Fuyin4; Fang, Shimeng2; Li, Xiaojie2; Li, Wuwei2; Yang, Xuesong5; Luo, Yong6; Lin, Bingcheng1,6 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2016-03-08 |
| 卷号 | 11期号:3 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0150247 |
| 文献子类 | Article |
| 英文摘要 | Carcinoma-associated fibroblasts (CAFs) are critical in determining tumor invasion and metastasis. However the role of CAFs in the invasion of salivary gland adenoid cystic carcinoma (ACC) is poorly understood. In this study, we isolated primary CAFs from two ACC patients. ACC-derived CAFs expressed typical CAF biomarkers and showed increased migration and invasion activity. Conditioned medium collected from CAFs significantly promoted ACC cell migration and invasion. Co-culture of CAFs with ACC cells in a microfluidic device further revealed that CAFs localized at the invasion front and ACC cells followed the track behind the CAFs. Interfering of both matrix metalloproteinase and CXCL12/CXCR4 pathway inhibited ACC invasion promoted by CAFs. Overall, our study demonstrates that ACC-derived CAFs exhibit the most important defining feature of CAFs by promoting cancer invasion. In addition to secretion of soluble factors, CAFs also lead ACC invasion by creating an invasive track in the ECM. |
| WOS关键词 | CANCER-ASSOCIATED FIBROBLASTS ; TUMOR MICROENVIRONMENT ; BREAST-CANCER ; LUNG-CANCER ; GROWTH ; PROGRESSION ; EXPRESSION ; METASTASIS ; MATRIX ; STROMA |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000371991300018 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171092]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Liu, Tingjiao |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian, Peoples R China 2.Dalian Med Univ, Coll Stomatol, Dalian, Peoples R China 3.Dalian Med Univ, Affiliated Hosp 1, Dept Oral Surg, Dalian, Peoples R China 4.Dalian Med Univ, Affiliated Hosp 2, Dept Oral Surg, Dalian, Peoples R China 5.Dalian Med Univ, Dept Biochem & Mol Biol, Dalian, Peoples R China 6.Dalian Univ Technol, Fac Chem Environm & Biol Sci & Technol, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jiao,Jia, Zhuqiang,Kong, Jing,et al. Carcinoma-Associated Fibroblasts Lead the Invasion of Salivary Gland Adenoid Cystic Carcinoma Cells by Creating an Invasive Track[J]. PLOS ONE,2016,11(3). |
| APA | Li, Jiao.,Jia, Zhuqiang.,Kong, Jing.,Zhang, Fuyin.,Fang, Shimeng.,...&Liu, Tingjiao.(2016).Carcinoma-Associated Fibroblasts Lead the Invasion of Salivary Gland Adenoid Cystic Carcinoma Cells by Creating an Invasive Track.PLOS ONE,11(3). |
| MLA | Li, Jiao,et al."Carcinoma-Associated Fibroblasts Lead the Invasion of Salivary Gland Adenoid Cystic Carcinoma Cells by Creating an Invasive Track".PLOS ONE 11.3(2016). |
入库方式： OAI收割
来源：大连化学物理研究所
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