Online Measurement of Exhaled NO Concentration and Its Production Sites by Fast Non-equilibrium Dilution Ion Mobility Spectrometry
文献类型：期刊论文
| 作者 | Peng, Liying1,2; Jiang, Dandan1,2; Wang, Zhenxin2; Liu, Jiwei3; Li, Haiyang2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-03-15 |
| 卷号 | 6 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep23095 |
| 文献子类 | Article |
| 英文摘要 | Exhaled nitric oxide (NO) is one of the most promising breath markers for respiratory diseases. Its profile for exhalation and the respiratory NO production sites can provide useful information for medical disease diagnosis and therapeutic procedures. However, the high-level moisture in exhaled gas always leads to the poor selectivity and sensitivity for ion spectrometric techniques. Herein, a method based on fast non-equilibrium dilution ion mobility spectrometry (NED-IMS) was firstly proposed to directly monitor the exhaled NO profile on line. The moisture interference was eliminated by turbulently diluting the original moisture to 21% of the original with the drift gas and dilution gas. Weak enhancement was observed for humid NO response and its limit of detection at 100% relative humidity was down to 0.58 ppb. The NO concentrations at multiple exhalation flow rates were measured, while its respiratory production sites were determined by using two-compartment model (2CM) and Hogman and Merilainen algorithm (HMA). Last but not the least, the NO production sites were analyzed hourly to tentatively investigate the daily physiological process of NO. The results demonstrated the capacity of NED-IMS in the real-time analysis of exhaled NO and its production sites for clinical diagnosis and assessment. |
| WOS关键词 | NITRIC-OXIDE EXCHANGE ; CLINICAL-APPLICATION ; ALLERGIC RHINITIS ; MASS-SPECTROMETRY ; ASTHMA ; CHEMILUMINESCENCE ; POPULATION ; ANALYZER ; TERM ; AIR |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000372050000002 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171098]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Li, Haiyang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Liaoning Normal Univ, Fac Chem & Chem Engn, Inst Chem Functionalized Mat, Dalian 116029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Liying,Jiang, Dandan,Wang, Zhenxin,et al. Online Measurement of Exhaled NO Concentration and Its Production Sites by Fast Non-equilibrium Dilution Ion Mobility Spectrometry[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Peng, Liying,Jiang, Dandan,Wang, Zhenxin,Liu, Jiwei,&Li, Haiyang.(2016).Online Measurement of Exhaled NO Concentration and Its Production Sites by Fast Non-equilibrium Dilution Ion Mobility Spectrometry.SCIENTIFIC REPORTS,6. |
| MLA | Peng, Liying,et al."Online Measurement of Exhaled NO Concentration and Its Production Sites by Fast Non-equilibrium Dilution Ion Mobility Spectrometry".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。