A non-derivative method for the quantitative analysis of isosteroidal alkaloids from Fritillaria by high performance liquid chromatography combined with charged aerosol detection
文献类型：期刊论文
| 作者 | Long, Zhen2; Guo, Zhimou3; Acworth, Ian N.1; Liu, Xiaoda2; Jin, Yan2; Liu, Xingguo2; Liu, Lvye2; Liang, Lina2 |
| 刊名 | TALANTA
 |
| 出版日期 | 2016-05-01 |
| 卷号 | 151页码:239-244 |
| 关键词 | Isosteroidal Alkaloids Weak Uv Absorbance Compound Charged Aerosol Detector Evaporative Light Scattering Detector Quantitative |
| ISSN号 | 0039-9140 |
| DOI | 10.1016/j.talanta.2016.01.027 |
| 文献子类 | Article |
| 英文摘要 | A non-derivative method was developed for the qualitative and quantitative analysis of isosteroidal alkaloids from Fritillaria thunbergii. During method development the performance of two universal detectors, the charged aerosol detector (CAD) and evaporative light scattering detector (ELSD), were evaluated. The CAD was found to be 30 to 55 times more sensitive than ELSD enabling the measurement of low levels of reference compound impurities that could not be detected by ELSD. The peak area percent of the reference compound, peimisine, obtained by CAD was 50.10%, but 91.66% by ELSD showing that CAD is suitable to estimate the presence of impurities. The CAD showed good reproducibility with overall intra- and inter-day peak area RSD values of less than 1.8% and 2.7%, respectively and had a linear dynamic range of up to 4 orders of magnitude (0.06-44 mg/L) for peimine and peiminine. The optimized method was used for the quantitative analysis of peimine and peiminine from F. thunbergii. (C) 2016 Published by Elsevier B.V. |
| WOS关键词 | LIGHT-SCATTERING DETECTION ; STATIONARY-PHASE ; BASIC COMPOUNDS ; UNIVERSAL RESPONSE ; IONIC-STRENGTH ; SEPARATION ; POLAR ; PURIFICATION ; SURFACE ; IMPURITIES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000372761900031 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171140]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Guo, Zhimou; Jin, Yan |
| 作者单位 | 1.Thermofisher Sci Corp, Chelmsford, MA 01824 USA 2.Thermofisher Sci Corp, Beijing 100080, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Long, Zhen,Guo, Zhimou,Acworth, Ian N.,et al. A non-derivative method for the quantitative analysis of isosteroidal alkaloids from Fritillaria by high performance liquid chromatography combined with charged aerosol detection[J]. TALANTA,2016,151:239-244. |
| APA | Long, Zhen.,Guo, Zhimou.,Acworth, Ian N..,Liu, Xiaoda.,Jin, Yan.,...&Liang, Lina.(2016).A non-derivative method for the quantitative analysis of isosteroidal alkaloids from Fritillaria by high performance liquid chromatography combined with charged aerosol detection.TALANTA,151,239-244. |
| MLA | Long, Zhen,et al."A non-derivative method for the quantitative analysis of isosteroidal alkaloids from Fritillaria by high performance liquid chromatography combined with charged aerosol detection".TALANTA 151(2016):239-244. |
入库方式： OAI收割
来源：大连化学物理研究所
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