The Effect of Codon Mismatch on the Protein Translation System
文献类型：期刊论文
| 作者 | Zhang, Dinglin1; Chen, Danfeng3; Cao, Liaoran1; Li, Guohui1; Cheng, Hong2 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2016-02-03 |
| 卷号 | 11期号:2 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0148302 |
| 文献子类 | Article |
| 英文摘要 | Incorrect protein translation, caused by codon mismatch, is an important problem of living cells. In this work, a computational model was introduced to quantify the effects of codon mismatch and the model was used to study the protein translation of Saccharomyces cerevisiae. According to simulation results, the probability of codon mismatch will increase when the supply of amino acids is unbalanced, and the longer is the codon sequence, the larger is the probability for incorrect translation to occur, making the synthesis of long peptide chain difficult. By comparing to simulation results without codon mismatch effects taken into account, the fraction of mRNAs with bound ribosome decrease faster along the mRNAs, making the 5' ramp phenomenon more obvious. It was also found in our work that the premature mechanism resulted from codon mismatch can reduce the proportion of incorrect translation when the amino acid supply is extremely unbalanced, which is one possible source of high fidelity protein synthesis after peptidyl transfer. |
| WOS关键词 | PEPTIDE-BOND FORMATION ; TRANSFER-RNAS ; RIBOSOMAL-SUBUNITS ; ELONGATION ; SEQUENCE ; YEAST ; DETERMINANTS ; EFFICIENCY ; INITIATION ; GENES |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000369550200121 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171194]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Li, Guohui; Cheng, Hong |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Lab Mol Modeling & Design, Dalian 116023, Liaoning, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl,State Key Lab Mol Bio, Shanghai 200031, Peoples R China 3.Dalian City Fisherles Tech Extens Stn, Dalian 116025, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Dinglin,Chen, Danfeng,Cao, Liaoran,et al. The Effect of Codon Mismatch on the Protein Translation System[J]. PLOS ONE,2016,11(2). |
| APA | Zhang, Dinglin,Chen, Danfeng,Cao, Liaoran,Li, Guohui,&Cheng, Hong.(2016).The Effect of Codon Mismatch on the Protein Translation System.PLOS ONE,11(2). |
| MLA | Zhang, Dinglin,et al."The Effect of Codon Mismatch on the Protein Translation System".PLOS ONE 11.2(2016). |
入库方式： OAI收割
来源：大连化学物理研究所
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