Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human
文献类型：期刊论文
| 作者 | Dai, Zi-Ru3; Yang, Ling3; Zou, Li-Wei3; Li, Wei4; Ma, Xiao-Chi5; Ge, Guang-Bo3; Ning, Jing2,3; Hou, Jie1; Wang, Ping3; Wu, Jing-Jing3 |
| 刊名 | XENOBIOTICA
 |
| 出版日期 | 2015 |
| 卷号 | 45期号:11页码:954-960 |
| 关键词 | 3-oxidation 5 Beta-hydroxylation Bufalin Cytochrome P450 3a Species Differences |
| ISSN号 | 0049-8254 |
| DOI | 10.3109/00498254.2015.1035359 |
| 文献子类 | Article |
| 英文摘要 | 1. Bufalin (BF), one of the major bioactive compounds in traditional Chinese medicine (TCM) Chansu, has been found with various pharmacological and toxicological effects. This study aims to investigate the species differences in phase I metabolism of BF in hepatic microsomes from human and five common experimental animals. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; HUMAN CYTOCHROME-P450 ; MICROBIAL TRANSFORMATION ; SPECIES-DIFFERENCES ; CARDIAC-GLYCOSIDES ; DRUG-METABOLISM ; BUFADIENOLIDES ; INHIBITION ; LIVER ; VITRO |
| WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000369949100002 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171214]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Ma, Xiao-Chi |
| 作者单位 | 1.Dalian Med Univ, Dept Biochem & Mol Biol, Dalian 116044, Peoples R China 2.Dalian Med Univ, Dalian 116044, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 4.Yangzhou Univ, Coll Med, Yangzhou 225009, Jiangsu, Peoples R China 5.Dalian Med Univ, Res Inst Integrated Tradit & Western Med, Western 9 Lvshun South Rd, Dalian 116044, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Zi-Ru,Yang, Ling,Zou, Li-Wei,et al. Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human[J]. XENOBIOTICA,2015,45(11):954-960. |
| APA | Dai, Zi-Ru.,Yang, Ling.,Zou, Li-Wei.,Li, Wei.,Ma, Xiao-Chi.,...&Wu, Jing-Jing.(2015).Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human.XENOBIOTICA,45(11),954-960. |
| MLA | Dai, Zi-Ru,et al."Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human".XENOBIOTICA 45.11(2015):954-960. |
入库方式： OAI收割
来源：大连化学物理研究所
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