Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver
文献类型：期刊论文
| 作者 | Wang, Wenyi3; Zhu, Hao2,3; Yan, Bing4; Zhang, Yi4; Wang, Yabin4; Liu, Aijuan4; Xu, Sherry Li5; Zhao, Bin5; Zhang, Yi1,6; Zou, Hanfa1 |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2016-02-09 |
| 卷号 | 26期号:6页码:841-850 |
| 关键词 | Combinatorial Chemistry Cyp450 Functionalized Mwcnts Human Liver Microsome Pharmacophores |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201504182 |
| 文献子类 | Article |
| 英文摘要 | The liver plays an important role in metabolizing foreign materials, such as drugs. The high accumulation of carbon nanotubes and other hydrophobic nanoparticles in the liver has raised concerns that nanoparticles may interfere with liver metabolic function. We report here that carbon nanotubes enter hepatic cells after intravenous introduction and interact with CYP enzymes, including CYP3A4. Surface chemical modifications alter the carbon nanotubes' interactions with CYP450 enzymes in human liver microsomes. They enhance, inhibit, or have no effect on the enzymatic function of CYP3A4. Using a cheminformatics analysis, certain chemical structures are identified on the surface of the carbon nanotubes that induce an enzyme inhibitory effect or prevent disruption of CYP3A4 enzymes. |
| WOS关键词 | IN-VIVO ; OXIDE NANOPARTICLES ; ACUTE TOXICITY ; DRUG-DELIVERY ; SILVER NANOPARTICLES ; GOLD NANOPARTICLES ; SURFACE-CHEMISTRY ; PROTEIN-BINDING ; FERRIC-OXIDE ; MICE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000370142500004 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171240]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Yan, Bing |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116011, Peoples R China 2.Rutgers State Univ, Dept Chem, Camden, NJ 08102 USA 3.Rutgers Ctr Computat & Integrat Biol, Camden, NJ 08102 USA 4.Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China 5.Res Ctr Ecoenvironm Sci CAS, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wenyi,Zhu, Hao,Yan, Bing,et al. Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver[J]. ADVANCED FUNCTIONAL MATERIALS,2016,26(6):841-850. |
| APA | Wang, Wenyi.,Zhu, Hao.,Yan, Bing.,Zhang, Yi.,Wang, Yabin.,...&Zou, Hanfa.(2016).Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver.ADVANCED FUNCTIONAL MATERIALS,26(6),841-850. |
| MLA | Wang, Wenyi,et al."Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver".ADVANCED FUNCTIONAL MATERIALS 26.6(2016):841-850. |
入库方式： OAI收割
来源：大连化学物理研究所
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