Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
文献类型：期刊论文
| 作者 | Long, Zijie8; Zheng, Feimeng4,5; Yue, Caifeng4,5,6; Li, Guohui7; He, Bin4,5; Cheng, Wei4,5; Qiu, Wanshou8; Yuan, Zhongyu4,5; Xu, Jie4,5; Liu, Bing4,5 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2016 |
| 卷号 | 7 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms10180 |
| 文献子类 | Article |
| 英文摘要 | Centrosome-localized mitotic Aurora kinase A (AURKA) facilitates G2/M events. Here we show that AURKA translocates to the nucleus and causes distinct oncogenic properties in malignant cells by enhancing breast cancer stem cell (BCSC) phenotype. Unexpectedly, this function is independent of its kinase activity. Instead, AURKA preferentially interacts with heterogeneous nuclear ribonucleoprotein K (hnRNP K) in the nucleus and acts as a transcription factor in a complex that induces a shift in MYC promoter usage and activates the MYC promoter. Blocking AURKA nuclear localization inhibits this newly discovered transactivating function of AURKA, sensitizing resistant BCSC to kinase inhibition. These findings identify a previously unknown oncogenic property of the spatially deregulated AURKA in tumorigenesis and provide a potential therapeutic opportunity to overcome kinase inhibitor resistance. |
| WOS关键词 | CHRONIC MYELOID-LEUKEMIA ; AURORA-A PHOSPHORYLATES ; C-MYC PROMOTER ; LUNG-CANCER ; TYROSINE KINASE ; N-MYC ; RESISTANCE ; IDENTIFICATION ; INHIBITORS ; EXPRESSION |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000369028400001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171314]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Liu, Quentin |
| 作者单位 | 1.China Med Univ, Grad Inst Canc Biol, 6 HSUEH SHIH Rd, Taichung 40402, Taiwan 2.Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, 1515 Holcombe Blvd, Houston, TX 77030 USA 3.China Med Univ, Ctr Mol Med, 6 HSUEH SHIH Rd, Taichung 40402, Taiwan 4.Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510275, Guangdong, Peoples R China 5.Dalian Med Univ, Inst Canc Stem Cell, 9 West Sect,Lvshun South Rd, Dalian 116044, Peoples R China 6.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Lab Med, 58 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China 7.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, 457 Zhongshan Rd, Dalian 116023, Peoples R China 8.Sun Yat Sen Univ, Affiliated Hosp 3, 600 Tianhe Rd, Guangzhou 510630, Guangdong, Peoples R China 9.Fudan Univ, Coll Life Sci, Inst Canc, Canc Hosp, 220 Handan Rd, Shanghai 200433, Peoples R China 10.Fudan Univ, Inst Biomed Sci, 220 Handan Rd, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Long, Zijie,Zheng, Feimeng,Yue, Caifeng,et al. Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype[J]. NATURE COMMUNICATIONS,2016,7. |
| APA | Long, Zijie.,Zheng, Feimeng.,Yue, Caifeng.,Li, Guohui.,He, Bin.,...&Wang, Xi.(2016).Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype.NATURE COMMUNICATIONS,7. |
| MLA | Long, Zijie,et al."Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype".NATURE COMMUNICATIONS 7(2016). |
入库方式： OAI收割
来源：大连化学物理研究所
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