Hydroxycinnamic acid amides from Scopolia tangutica inhibit the activity of M1 muscarinic acetylcholine receptor in vitro
文献类型：期刊论文
| 作者 | Zhang, Yan1; Long, Zhen3; Guo, Zhimou3; Wang, Zhiwei2; Zhang, Xiuli3; Ye, Richard D.1; Liang, Xinmiao3; Civelli, Olivier2 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2016 |
| 卷号 | 108页码:9-12 |
| ISSN号 | 0367-326X |
| 关键词 | Scopolia Tangutica Maxim Hydroxycinnamic Acid Amides M1 Muscarinic Acetylcholine Receptor |
| DOI | 10.1016/j.fitote.2015.11.007 |
| 文献子类 | Article |
| 英文摘要 | Scopolia tangutica Maxim (S. tangutica) extracts have been traditionally used as antispasmodic, sedative, and analgesic agents in Tibet and in the Qinghai province of China. Their active compositions are however poorly understood. We have recently isolated five new hydroxycinnamic acid (HCA) amides along with two known HCA amides, one cinnamic acid amide from these extracts. In this study, we evaluate their abilities to inhibit carbacol-induced activity of M1 muscarinic acetylcholine receptor along with the crude extracts. Chinese hamster ovary cells stably expressing the recombinant human M1 receptor (CHO-M1 cells) were employed to evaluate the anticholinergic potentials. Intracellular Ca2+ changes were monitored using the FLIPR system. Five HCA amides as well as the crude S. tangutica extract displayed dose-dependent inhibitory effects against M1 receptor. These findings demonstrate that HCA amides are part of the M1 receptor-inhibiting principles of S. tangutica. Since blockade of parasympathetic nerve impulse transmission through the inhibition of the M1 receptor lessens smooth muscle spasms, our findings provided a molecular explanation for the traditional use of S. tangutica against spasm. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS关键词 | QUERCUS-DENTATA ; POLYAMINES ; ALKALOIDS ; SPERMIDINES ; ANISODAMINE ; SCOPOLAMINE ; DESIGN ; POLLEN ; AGENTS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000368962900003 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171346]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhang, Yan |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China 2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA 3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Key Lab Nat Med, Dalian 116023, Liaoning Provin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yan,Long, Zhen,Guo, Zhimou,et al. Hydroxycinnamic acid amides from Scopolia tangutica inhibit the activity of M1 muscarinic acetylcholine receptor in vitro[J]. FITOTERAPIA,2016,108:9-12. |
| APA | Zhang, Yan.,Long, Zhen.,Guo, Zhimou.,Wang, Zhiwei.,Zhang, Xiuli.,...&Civelli, Olivier.(2016).Hydroxycinnamic acid amides from Scopolia tangutica inhibit the activity of M1 muscarinic acetylcholine receptor in vitro.FITOTERAPIA,108,9-12. |
| MLA | Zhang, Yan,et al."Hydroxycinnamic acid amides from Scopolia tangutica inhibit the activity of M1 muscarinic acetylcholine receptor in vitro".FITOTERAPIA 108(2016):9-12. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。