Reevaluation of the stability of G-quadruplex structures under crowding conditions
文献类型：期刊论文
| 作者 | Zhou, Jun3,4; Tateishi-Karimata, Hisae5,6; Mergny, Jean-Louis1,2; Cheng, Mingpan3; Feng, Zhaochi3; Miyoshi, Daisuke5,6; Sugimoto, Naoki5,6; Li, Can3 |
| 刊名 | BIOCHIMIE
 |
| 出版日期 | 2016-02-01 |
| 卷号 | 121页码:204-208 |
| 关键词 | G-quadruplex Stability Molecular Crowding Hydration Divalent Cations |
| ISSN号 | 0300-9084 |
| DOI | 10.1016/j.biochi.2015.12.012 |
| 文献子类 | Article |
| 英文摘要 | To evaluate the stability of G-quadruplex structures comprehensively, parallel (type I), antiparallel (type II), and hybrid (type III) G-quadruplexes in the presence of monovalent and divalent cations were assessed by UV-melting technique under dilute and crowded conditions. In the presence of monovalent cations, the stability of G-quadruplexes was increased by the presence of molecular crowding agents. Surprisingly, crowding agents stabilized parallel G-quadruplex, but had no effect on stability or destabilized antiparallel or hybrid G-quadruplex structures in the presence of divalent cations. A hydration study of the antiparallel G-quadruplex revealed that more water molecules are bound in the presence of divalent cations than with monovalent ions. These analyses under conditions that mimic those in cells further our understanding of how G-quadruplex structures are involved in biological processes. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved. |
| WOS关键词 | INTRAMOLECULAR G-QUADRUPLEX ; HUMAN TELOMERIC SEQUENCE ; CIRCULAR-DICHROISM ; K+ SOLUTION ; NUCLEIC-ACIDS ; LOOP LENGTH ; DNA ; HYDRATION ; BINDING ; FORMS |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000369679700023 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171406]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhou, Jun; Li, Can |
| 作者单位 | 1.Univ Bordeaux, F-33000 Bordeaux, France 2.INSERM, U869, IECB, F-33600 Pessac, France 3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China 4.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Jiangsu, Peoples R China 5.Konan Univ, Dept Frontier Inst Biomol Engn Res FIBER, Chuo Ku, 7-1-20 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan 6.Konan Univ, Grad Sch Frontiers Innovat Res Sci & Technol FIRS, Chuo Ku, 7-1-20 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan |
| 推荐引用方式 GB/T 7714 | Zhou, Jun,Tateishi-Karimata, Hisae,Mergny, Jean-Louis,et al. Reevaluation of the stability of G-quadruplex structures under crowding conditions[J]. BIOCHIMIE,2016,121:204-208. |
| APA | Zhou, Jun.,Tateishi-Karimata, Hisae.,Mergny, Jean-Louis.,Cheng, Mingpan.,Feng, Zhaochi.,...&Li, Can.(2016).Reevaluation of the stability of G-quadruplex structures under crowding conditions.BIOCHIMIE,121,204-208. |
| MLA | Zhou, Jun,et al."Reevaluation of the stability of G-quadruplex structures under crowding conditions".BIOCHIMIE 121(2016):204-208. |
入库方式： OAI收割
来源：大连化学物理研究所
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