Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells
文献类型：期刊论文
| 作者 | Qun, E.4; Tang, Miao2,5; Zhang, XiaoChuan2,5; Shi, YunWei2,5; Wang, DanDan2,5; Gu, Yun2,5; Li, ShiYing2,5; Liang, XinMiao1,2,5; Wang, ZhiWei2,3,5; Wang, CaiPing2,5 |
| 刊名 | CELL BIOLOGY INTERNATIONAL
 |
| 出版日期 | 2015-12-01 |
| 卷号 | 39期号:12页码:1418-1424 |
| 关键词 | Apoptosis Dibenzocyclooctadiene Lignans Inflammation Neuroprotection Schisandra Chinensis |
| ISSN号 | 1065-6995 |
| DOI | 10.1002/cbin.10537 |
| 文献子类 | Article |
| 英文摘要 | Dibenzocyclooctadiene lignans, the major active components of fruit of Schisandra chinensis (Turcz.) Baill., have been found to have activities that could prevent prostate and thyroid cancer, hepatotoxicity, oxidative stress-induced cerebral injury, etc. This study was conducted to evaluate the effects of seven dibenzocyclooctadiene lignans of Schisandra chinensis and explore the possible mechanisms in the human neuroblastoma SH-SY5Y cells exposed on serum and glucose deprivation (SGD) injury. The structure-activity relationships were also analyzed. Cell viability and lactate dehydrogenase (LDH) release were determined to evaluate cell injury. Inflammation and apoptosis-related protein levels were detected to elucidate the possible mechanisms. Schisantherin A, schizandrin C, and schizandrol B were found to have stronger protective effects than schizandrin A, schizandrin B, and schisanhenol in SH-SY5Y cells against SGD injury. Moreover, the protective effects of these lignans were possibly exhibited by regulating inflammation and apoptosis-related proteins in SH-SY5Y cells after SGD injury, supporting their beneficial effects for the prevention of cell injury in the pathogenesis of the central nervous system diseases, including ischemia stroke. The number and position of hydroxyl group and methylenedioxy in these lignans may be required for their effects. |
| WOS关键词 | NF-KAPPA-B ; CORTICAL-NEURONS ; ISCHEMIC-STROKE ; BRAIN ; RATS ; MICE ; SCHISANTHERIN ; REPERFUSION ; EXTRACT ; PATHWAY |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000368072300007 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171498]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Liang, XinMiao |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China 3.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA 4.Nantong Univ, Sch Med, Dept Pathol, Nantong 226001, Peoples R China 5.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qun, E.,Tang, Miao,Zhang, XiaoChuan,et al. Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells[J]. CELL BIOLOGY INTERNATIONAL,2015,39(12):1418-1424. |
| APA | Qun, E..,Tang, Miao.,Zhang, XiaoChuan.,Shi, YunWei.,Wang, DanDan.,...&Wang, CaiPing.(2015).Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells.CELL BIOLOGY INTERNATIONAL,39(12),1418-1424. |
| MLA | Qun, E.,et al."Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells".CELL BIOLOGY INTERNATIONAL 39.12(2015):1418-1424. |
入库方式： OAI收割
来源：大连化学物理研究所
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