Integration of Metabolomics and Transcriptomics Reveals Major Metabolic Pathways and Potential Biomarker Involved in Prostate Cancer
文献类型：期刊论文
| 作者 | Ren, Shancheng1; Shao, Yaping3; Zhao, Xinjie3; Hong, Christopher S.2; Wang, Fubo1; Lu, Xin3; Li, Jia3; Ye, Guozhu3; Yan, Min3; Zhuang, Zhengping2 |
| 刊名 | MOLECULAR & CELLULAR PROTEOMICS
 |
| 出版日期 | 2016 |
| 卷号 | 15期号:1页码:154-163 |
| ISSN号 | 1535-9476 |
| DOI | 10.1074/mcp.M115.052381 |
| 文献子类 | Article |
| 英文摘要 | Prostate cancer is a highly prevalent tumor affecting millions of men worldwide, but poor understanding of its pathogenesis has limited effective clinical management of patients. In addition to transcriptional profiling or transcriptomics, metabolomics is being increasingly utilized to discover key molecular changes underlying tumorigenesis. In this study, we integrated transcriptomics and metabolomics to analyze 25 paired human prostate cancer tissues and adjacent noncancerous tissues, followed by further validation of our findings in an additional cohort of 51 prostate cancer patients and 16 benign prostatic hyperplasia patients. We found several altered pathways aberrantly expressed at both metabolic and transcriptional levels, including cysteine and methionine metabolism, nicotinamide adenine dinucleotide metabolism, and hexosamine biosynthesis. Additionally, the metabolite sphingosine demonstrated high specificity and sensitivity for distinguishing prostate cancer from benign prostatic hyperplasia, particularly for patients with low prostate specific antigen level (0-10 ng/ml). We also found impaired sphingosine-1-phosphate receptor 2 signaling, downstream of sphingosine, representing a loss of tumor suppressor gene and a potential key oncogenic pathway for therapeutic targeting. By integrating metabolomics and transcriptomics, we have provided both a broad picture of the molecular perturbations underlying prostate cancer and a preliminary study of a novel metabolic signature, which may help to discriminate prostate cancer from normal tissue and benign prostatic hyperplasia. |
| WOS关键词 | GLYCINE-N-METHYLTRANSFERASE ; TERT-BUTYL ETHER ; SPHINGOSINE 1-PHOSPHATE ; EXPRESSION ANALYSIS ; CELL MIGRATION ; PROGRESSION ; SPHINGOSINE-1-PHOSPHATE ; TRANSFERASE ; METASTASIS ; RECEPTOR |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000367461000011 |
| 出版者 | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171516]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Xu, Guowang |
| 作者单位 | 1.Second Mil Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai, Peoples R China 2.NINDS, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA 3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Shancheng,Shao, Yaping,Zhao, Xinjie,et al. Integration of Metabolomics and Transcriptomics Reveals Major Metabolic Pathways and Potential Biomarker Involved in Prostate Cancer[J]. MOLECULAR & CELLULAR PROTEOMICS,2016,15(1):154-163. |
| APA | Ren, Shancheng.,Shao, Yaping.,Zhao, Xinjie.,Hong, Christopher S..,Wang, Fubo.,...&Sun, Yinghao.(2016).Integration of Metabolomics and Transcriptomics Reveals Major Metabolic Pathways and Potential Biomarker Involved in Prostate Cancer.MOLECULAR & CELLULAR PROTEOMICS,15(1),154-163. |
| MLA | Ren, Shancheng,et al."Integration of Metabolomics and Transcriptomics Reveals Major Metabolic Pathways and Potential Biomarker Involved in Prostate Cancer".MOLECULAR & CELLULAR PROTEOMICS 15.1(2016):154-163. |
入库方式： OAI收割
来源：大连化学物理研究所
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