Surface Stiffness-a Parameter for Sensing the Chirality of Saccharides
文献类型：期刊论文
| 作者 | Lv, Ziyu4; Li, Xiuling2; Chen, Zhonghui4; Chen, Ji1; Chen, Cheng2; Xiong, Peng4; Sun, Taolei3,4; Qing, Guangyan4 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2015-12-16 |
| 卷号 | 7期号:49页码:27223-27233 |
| ISSN号 | 1944-8244 |
| 关键词 | Surface Stiffness Viscoelasticity Stimuli-responsive Films Chiral Separation Tissue Engineering |
| DOI | 10.1021/acsami.5b08405 |
| 文献子类 | Article |
| 英文摘要 | Surface stiffness is considered a key parameter for designing high-performance implantable materials and artificial extracellular matrices because of its substantial effects on cell behavior. How to transform biomolecule recognition events, particularly chiral recognition, into stiffness change on material surfaces is biologically essential but very challenging for chemists. Here, we report a chirality-triggered stiffness transition on a smart polymer film, which consists of flexible polyethylenimine (PEI) main chains grafted with dipeptide units capable of discriminating chiral monosaccharides. The polymer film became substantially softer after interacting with L-ribose and became more rigid after interacting with D-ribose (the basic building block of DNA and RNA). This chiral effect provides a new method for determining the enantiomeric purity of an L/D-ribose mixture and facilitates the chiral separation of deoxyribose racemates as well as the separation of diverse mono-, di-, and oligosaccharides. These are three puzzle problems in carbohydrate chemistry. Furthermore, taking advantage of the significant differences in the surface stiffness, the proliferation of fibroblast cells on the polymeric surfaces can also be regulated by chiral biomolecules. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; QUARTZ-CRYSTAL MICROBALANCE ; STEM-CELL FATE ; SUBSTRATE STIFFNESS ; ENANTIOMERIC EXCESS ; INTERFACE ; POLYMER ; ADHESION ; MANIPULATION ; NANOFIBRILS |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000366873900024 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171528]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Qing, Guangyan |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Wuhan Univ Technol, Chem Engn & Life Sci, Sch Chem, Wuhan 430070, Peoples R China 4.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Ziyu,Li, Xiuling,Chen, Zhonghui,et al. Surface Stiffness-a Parameter for Sensing the Chirality of Saccharides[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(49):27223-27233. |
| APA | Lv, Ziyu.,Li, Xiuling.,Chen, Zhonghui.,Chen, Ji.,Chen, Cheng.,...&Qing, Guangyan.(2015).Surface Stiffness-a Parameter for Sensing the Chirality of Saccharides.ACS APPLIED MATERIALS & INTERFACES,7(49),27223-27233. |
| MLA | Lv, Ziyu,et al."Surface Stiffness-a Parameter for Sensing the Chirality of Saccharides".ACS APPLIED MATERIALS & INTERFACES 7.49(2015):27223-27233. |
入库方式： OAI收割
来源：大连化学物理研究所
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