The cause and influence of sequentially assembling higher and lower deacetylated chitosans on the membrane formation of microcapsule
文献类型：期刊论文
| 作者 | Zheng, Guoshuang2,3; Zheng, Huizhen2,3; Xie, Hongguo2; Liu, Xiudong1; Yu, Weiting2; Ma, Xiaojun2 |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
 |
| 出版日期 | 2016 |
| 卷号 | 104期号:1页码:257-263 |
| 关键词 | Alginate-chitosan Microcapsule Sequential Assembly Molecular Migration Surface Roughness Binding Amount |
| ISSN号 | 1549-3296 |
| DOI | 10.1002/jbm.a.35562 |
| 文献子类 | Article |
| 英文摘要 | Alginate-chitosan (AC) microcapsules with desired strength and biocompatibility are preferred in cell-based therapy. Sequential assembly of higher and lower deacetylated chitosans (C-1 and C-2) on alginate has produced AC(1)C(2) microcapsule with improved membrane strength and biocompatibility. In this article, the assembly and complexation processes of two cationic chitosans on anionic alginate were concerned, and the cause and influence of sequentially assembling chitosans on AC(1)C(2) microcapsules membrane formation were evaluated. It was found that C-1 complexation was the key factor for deciding the membrane thickness of AC(1)C(2) microcapsule. Specifically, the binding amount of C-2 positively related to the binding amount of C-1, which suggested the first layer by C-1 complexation on alginate had no obvious resistance on the sequential cationic C-2 complexation. Further analyses demonstrated that outward migration of alginate molecules and inward diffusion of both chitosans under electrostatic interaction contributed to the sequential coating of C-2 on first C-1 layer. Moreover, C-2 complexation through the surface to inner layer of membrane helped smoothen the first layer by C-1 complexation that displayed a synergy role on the formation of AC(1)C(2) microcapsule membrane. Therefore, the two chitosans played different roles and synergistically contributed to membrane properties that can be easily regulated with membrane complexation time. (c) 2015 Wiley Periodicals, Inc. |
| WOS关键词 | ALGINATE/CHITOSAN HYDROGEL MICROCAPSULES ; IN-VITRO ; CELL ENCAPSULATION ; ALGINATE ; BIOCOMPATIBILITY ; STRENGTH ; CAPSULES ; BEHAVIOR ; BEADS ; MPEG |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000366451000027 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171532]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Yu, Weiting |
| 作者单位 | 1.Dalian Univ, Dalian Econ Technol Dev Zone, Coll Environm & Chem Engn, Dalian 116622, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Lab Biomed Mat Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Guoshuang,Zheng, Huizhen,Xie, Hongguo,et al. The cause and influence of sequentially assembling higher and lower deacetylated chitosans on the membrane formation of microcapsule[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2016,104(1):257-263. |
| APA | Zheng, Guoshuang,Zheng, Huizhen,Xie, Hongguo,Liu, Xiudong,Yu, Weiting,&Ma, Xiaojun.(2016).The cause and influence of sequentially assembling higher and lower deacetylated chitosans on the membrane formation of microcapsule.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,104(1),257-263. |
| MLA | Zheng, Guoshuang,et al."The cause and influence of sequentially assembling higher and lower deacetylated chitosans on the membrane formation of microcapsule".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 104.1(2016):257-263. |
入库方式： OAI收割
来源：大连化学物理研究所
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