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Synthesis, Crystal Structures and Urease Inhibition of N '-(2-Bromobenzylidene)-2-(4-nitrophenoxy)acetohydrazide and N '-(4-Nitrobenzylidene)-2-(4-nitrophenoxy)acetohydrazide

文献类型：期刊论文

作者Sheng, Gui-Hua3; Chen, Xiang-Fei3; Li, Jian3; Chen, Jie3; Xu, Ying3; Han, Yan-Wei3; Yang, Ting2; You, Zhonglu1; Zhu, Hai-Liang3
刊名ACTA CHIMICA SLOVENICA
出版日期2015
卷号62期号:4页码:940-946
关键词Hydrazone Crystal Structure Hydrogen Bonds X-ray Diffraction Urease Inhibition
ISSN号1318-0207
文献子类Article
英文摘要Two new hydrazone compounds, N'-(2-bromobenzylidene)-2-(4-nitrophenoxy)acetohydrazide (1) and N'-(4-nitrobenzylidene)-2-(4-nitrophenoxy)acetohydrazide (2), were prepared and characterized by elemental analysis, IR, UV-Vis and H-1 NMR spectroscopy, and single-crystal X-ray diffraction. Compound 1 crystallizes in the monoclinic space group P2(1)/n with unit cell dimensions of a = 5.3064(5) angstrom, b = 18.202(2) angstrom, c = 15.970(2) angstrom, beta = 95.866(3)degrees, V = 1534.4(2) angstrom(3), Z = 4, R-1 = 0.0457, and wR(2) = 0.0975. Compound 2 crystallizes in the monoclinic space group P2(1)/c with unit cell dimensions of a = 4.6008(7) angstrom, b = 14.451(2) angstrom, c = 23.296(3) angstrom, beta = 93.620(2)degrees, V = 1545.8(4) angstrom(3), Z = 4, R-1 = 0.0441, and wR(2) = 0.0985. Structures of the compounds are stabilized by hydrogen bonds and pi center dot center dot center dot pi interactions. The urease inhibitory activities of the compounds were studied. Both compounds show strong urease inhibitory activities, with IC50 values of 8.4 and 20.2 mu M, respectively.
WOS关键词MOLECULAR DOCKING ; HYDROXAMIC ACIDS ; DERIVATIVES ; COMPLEXES ; AMMONIA ; LIGANDS
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000367042900026
出版者SLOVENSKO KEMIJSKO DRUSTVO
源URL[http://cas-ir.dicp.ac.cn/handle/321008/171538]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者You, Zhonglu
作者单位1.Liaoning Normal Univ, Dept Chem & Chem Engn, Dalian 116029, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Shandong Univ Technol, Sch Life Sci, Zibo 255049, Peoples R China
推荐引用方式
GB/T 7714		 Sheng, Gui-Hua,Chen, Xiang-Fei,Li, Jian,et al. Synthesis, Crystal Structures and Urease Inhibition of N '-(2-Bromobenzylidene)-2-(4-nitrophenoxy)acetohydrazide and N '-(4-Nitrobenzylidene)-2-(4-nitrophenoxy)acetohydrazide[J]. ACTA CHIMICA SLOVENICA,2015,62(4):940-946.
APA Sheng, Gui-Hua.,Chen, Xiang-Fei.,Li, Jian.,Chen, Jie.,Xu, Ying.,...&Zhu, Hai-Liang.(2015).Synthesis, Crystal Structures and Urease Inhibition of N '-(2-Bromobenzylidene)-2-(4-nitrophenoxy)acetohydrazide and N '-(4-Nitrobenzylidene)-2-(4-nitrophenoxy)acetohydrazide.ACTA CHIMICA SLOVENICA,62(4),940-946.
MLA Sheng, Gui-Hua,et al."Synthesis, Crystal Structures and Urease Inhibition of N '-(2-Bromobenzylidene)-2-(4-nitrophenoxy)acetohydrazide and N '-(4-Nitrobenzylidene)-2-(4-nitrophenoxy)acetohydrazide".ACTA CHIMICA SLOVENICA 62.4(2015):940-946.

入库方式： OAI收割

来源：大连化学物理研究所

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