The Separation and Enrichment of Glycoproteins or Glycopeptides Based on Nanoparticles
文献类型：期刊论文
| 作者 | Ding Peng2; Chen Xian2; Li Xiuling1; Qing Guangyan2; Sun Taolei2,3; Liang Xinmiao1 |
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2015-11-01 |
| 卷号 | 27期号:11页码:1628-1639 |
| 关键词 | Glycoproteomics Glycoproteins Glycopeptides Nanoparticles Enrichment |
| ISSN号 | 1005-281X |
| DOI | 10.7536/PC150513 |
| 文献子类 | Review |
| 英文摘要 | As one of the most important post-translational modifications, protein glycosylation has a significant effect on the structures and functions of proteins. Many low-abundance endogenous glycoproteins/glycopeptides in the serum or tissue extracts are biomarkers with higher clinical sensitivity and specificity, which could provide valuable information to explore the pathogenesis of many diseases, discover disease biomarkers and develop proteins based new drugs. However, it is still a great challenge for glycoproteomics to selectively separate and enrich the glycoproteins/glycopeptides from the complex biological samples due to their extremely low concentrations. Nanoparticle materials have been attracted much attention in the separation and enrichment of glycoproteins/glycopeptides due to their large surface to volume ratio, numerous affinity sites and unique structures. In this work, the recent progress for the separation and enrichment of glycoproteins/glycopeptides based on the nanoparticles, including gold, SiO2, TiO2, nanodiamond and polymer nanoparticles are reviewed. Finally, the challenges and prospects for the methods of the separation and enrichment of glycoproteins/glycopeptides are briefly proposed. |
| WOS关键词 | N-LINKED GLYCOPEPTIDES ; HIGHLY SPECIFIC ENRICHMENT ; FUNCTIONALIZED MAGNETIC NANOPARTICLES ; MASS-SPECTROMETRIC CHARACTERIZATION ; TITANIUM-DIOXIDE CHROMATOGRAPHY ; CORE-SHELL MICROSPHERES ; TOF MS ANALYSIS ; SELECTIVE ENRICHMENT ; FACILE SYNTHESIS ; MESOPOROUS SILICA |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000365933100010 |
| 出版者 | CHINESE ACAD SCIENCES |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171576]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Li Xiuling |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China 3.Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding Peng,Chen Xian,Li Xiuling,et al. The Separation and Enrichment of Glycoproteins or Glycopeptides Based on Nanoparticles[J]. PROGRESS IN CHEMISTRY,2015,27(11):1628-1639. |
| APA | Ding Peng,Chen Xian,Li Xiuling,Qing Guangyan,Sun Taolei,&Liang Xinmiao.(2015).The Separation and Enrichment of Glycoproteins or Glycopeptides Based on Nanoparticles.PROGRESS IN CHEMISTRY,27(11),1628-1639. |
| MLA | Ding Peng,et al."The Separation and Enrichment of Glycoproteins or Glycopeptides Based on Nanoparticles".PROGRESS IN CHEMISTRY 27.11(2015):1628-1639. |
入库方式： OAI收割
来源：大连化学物理研究所
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