Challenges and Solutions of Pharmacokinetics for Efficacy and Safety of Traditional Chinese Medicine
文献类型：期刊论文
| 作者 | Li, Yazhuo2; Wang, Yanli3; Tai, Wen3; Yang, Ling1; Chen, Yong4; Chen, Changqing3; Liu, Changxiao2 |
| 刊名 | CURRENT DRUG METABOLISM
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:9页码:765-776 |
| 关键词 | Pharmacokinetics Traditional Chinese Medicines |
| ISSN号 | 1389-2002 |
| 文献子类 | Article |
| 英文摘要 | Traditional Chinese medicine (TCM), including herbal and folk medicine have been widely applied in healthcare field for a very long time. Based on the principle of kinetics, pharmacokinetics of TCM was developed to investigate the absorption, distribution, metabolism and excretion of active ingredients/components, single or mixed formulations, as well as the relationship between concentration and efficacy presented. Due to the complexity of TCM and its preparation, selection of molecules as markers for detection has become very difficult. So far, in which way or what indicators can be chosen for representing the pharmacodynamic action of single TCM or mixed is still controversial. Currently, a widely accepted approach is that the action of mixed preparation can be correlated by detecting pharmacokinetic behavior of one or several known active ingredients. According to the complexity of TCM, we presented a new concept of pharmacokinetic (PK) marker. The PK Marker should possess three conditions: (1) PK marker must be associated with efficacy, (2) PK marker exists in biological sample and can be determined by analytic method, and (3) PK marker should reflect the relationship between concentration and time. In TCM, four elements, "king-minister-assistant-guide", are the basic prescription principles for the individual therapy in TCM. We presented an idea of Point-line-area-cubic for four elements of TCM to study herb-herb interactions. |
| WOS关键词 | H-1-NMR SPECTROSCOPY ; METABONOMIC ANALYSIS ; MASS-SPECTROMETRY ; RAT URINE ; PLASMA ; TRANSPORTERS ; METABOLISM ; SYSTEMS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000365624600005 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171598]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Liu, Changxiao |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R China 3.Tianjin Inst Pharmaceut Res, Ctr Informat, Tianjin 300193, Peoples R China 4.Hubei Univ, Wuhan 430062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yazhuo,Wang, Yanli,Tai, Wen,et al. Challenges and Solutions of Pharmacokinetics for Efficacy and Safety of Traditional Chinese Medicine[J]. CURRENT DRUG METABOLISM,2015,16(9):765-776. |
| APA | Li, Yazhuo.,Wang, Yanli.,Tai, Wen.,Yang, Ling.,Chen, Yong.,...&Liu, Changxiao.(2015).Challenges and Solutions of Pharmacokinetics for Efficacy and Safety of Traditional Chinese Medicine.CURRENT DRUG METABOLISM,16(9),765-776. |
| MLA | Li, Yazhuo,et al."Challenges and Solutions of Pharmacokinetics for Efficacy and Safety of Traditional Chinese Medicine".CURRENT DRUG METABOLISM 16.9(2015):765-776. |
入库方式： OAI收割
来源：大连化学物理研究所
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