Improvement of chiral stationary phases based on cinchona alkaloids bonded to crown ethers by chiral modification
文献类型：期刊论文
| 作者 | Zhao, Jianchao1; Wu, Haixia1; Wang, Dongqiang1; Wu, Haibo1; Cheng, Lingping1; Jin, Yu1; Ke, Yanxiong1,2 |
| 刊名 | JOURNAL OF SEPARATION SCIENCE
 |
| 出版日期 | 2015-11-01 |
| 卷号 | 38期号:22页码:3884-3890 |
| 关键词 | Amino Acids Chiral Selectors Cinchona Alkaloids Crown Ethers Enantioseparation |
| ISSN号 | 1615-9306 |
| DOI | 10.1002/jssc.201500834 |
| 文献子类 | Article |
| 英文摘要 | To improve the chiral recognition capability of a cinchona alkaloid crown ether chiral stationary phase, the crown ether moiety was modified by the chiral group of (1S, 2S)-2-aminocyclohexyl phenylcarbamate. Both quinine and quinidine-based stationary phases were evaluated by chiral acids, chiral primary amines and amino acids. The quinine/quinidine and crown ether provided ion-exchange sites and complex interaction site for carboxyl group and primary amine group in amino acids, respectively, which were necessary for the chiral discrimination of amino acid enantiomers. The introduction of the chiral group greatly improved the chiral recognition for chiral primary amines. The structure of crown ether moiety was proved to play a dominant role in the chiral recognitions for chiral primary amines and amino acids. |
| WOS关键词 | LIQUID-CHROMATOGRAPHIC RESOLUTION ; ZWITTERION-EXCHANGE MODES ; AMINO-ACIDS ; (+)-(18-CROWN-6)-2,3,11,12-TETRACARBOXYLIC ACID ; ENANTIOSEPARATION CHARACTERISTICS ; PSEUDO-18-CROWN-6 ETHER ; ENANTIOMER SEPARATION ; CYCLIC POLYETHERS ; MOBILE-PHASE ; METAL-SALTS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000365320800010 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171616]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Ke, Yanxiong |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Jianchao,Wu, Haixia,Wang, Dongqiang,et al. Improvement of chiral stationary phases based on cinchona alkaloids bonded to crown ethers by chiral modification[J]. JOURNAL OF SEPARATION SCIENCE,2015,38(22):3884-3890. |
| APA | Zhao, Jianchao.,Wu, Haixia.,Wang, Dongqiang.,Wu, Haibo.,Cheng, Lingping.,...&Ke, Yanxiong.(2015).Improvement of chiral stationary phases based on cinchona alkaloids bonded to crown ethers by chiral modification.JOURNAL OF SEPARATION SCIENCE,38(22),3884-3890. |
| MLA | Zhao, Jianchao,et al."Improvement of chiral stationary phases based on cinchona alkaloids bonded to crown ethers by chiral modification".JOURNAL OF SEPARATION SCIENCE 38.22(2015):3884-3890. |
入库方式： OAI收割
来源：大连化学物理研究所
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