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ALYREF links 3-end processing to nuclear export of non-polyadenylated mRNAs

文献类型：期刊论文

作者Fan, Jing4; Wang, Ke2,4; Du, Xian; Wang, Jianshu4; Chen, Suli4; Wang, Yimin4; Shi, Min4; Zhang, Li4; Wu, Xudong3; Zheng, Dinghai1
刊名EMBO JOURNAL
出版日期2019-05-02
卷号38期号:9页码:16
关键词3-end processing ALYREF mRNA export RD-histone mRNA SLBP
ISSN号0261-4189
DOI10.15252/embj.201899910
通讯作者Cheng, Hong(hcheng@sibcb.ac.cn)
英文摘要The RNA-binding protein ALYREF plays key roles in nuclear export and also 3-end processing of polyadenylated mRNAs, but whether such regulation also extends to non-polyadenylated RNAs is unknown. Replication-dependent (RD)-histone mRNAs are not polyadenylated, but instead end in a stem-loop (SL) structure. Here, we demonstrate that ALYREF prevalently binds a region next to the SL on RD-histone mRNAs. SL-binding protein (SLBP) directly interacts with ALYREF and promotes its recruitment. ALYREF promotes histone pre-mRNA 3-end processing by facilitating U7-snRNP recruitment through physical interaction with the U7-snRNP-specific component Lsm11. Furthermore, ALYREF, together with other components of the TREX complex, enhances histone mRNA export. Moreover, we show that 3-end processing promotes ALYREF recruitment and histone mRNA export. Together, our results point to an important role of ALYREF in coordinating 3-end processing and nuclear export of non-polyadenylated mRNAs.
WOS关键词LOOP BINDING-PROTEIN ; HUMAN TREX COMPLEX ; 3' END ; U7 SNRNP ; FACTOR YRA1 ; STEM ; 3'-END ; LSM11 ; INTERACTS ; FLASH
资助项目National Key R&D Program of China[2017YFA0504400] ; National Natural Science Foundation of China[31570822] ; National Natural Science Foundation of China[31770880] ; National Natural Science Foundation of China[31800686] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19000000] ; China Postdoctoral Science Foundation[2018M630481] ; China Postdoctoral Science Foundation[BX20180333]
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
WOS记录号WOS:000468399700010
出版者WILEY
资助机构National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation
源URL[http://cas-ir.dicp.ac.cn/handle/321008/171847]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Cheng, Hong
作者单位1.Rutgers New Jersey Med Sch, Dept Microbiol Biochem & Mol Genet, Newark, NJ USA
2.Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan, Hubei, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Lab Mol Modeling & Design, Dalian, Peoples R China
4.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci,CAS, Shanghai Key Lab Mol Androl,State Key Lab Mol Bio, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Fan, Jing,Wang, Ke,Du, Xian,et al. ALYREF links 3-end processing to nuclear export of non-polyadenylated mRNAs[J]. EMBO JOURNAL,2019,38(9):16.
APA Fan, Jing.,Wang, Ke.,Du, Xian.,Wang, Jianshu.,Chen, Suli.,...&Cheng, Hong.(2019).ALYREF links 3-end processing to nuclear export of non-polyadenylated mRNAs.EMBO JOURNAL,38(9),16.
MLA Fan, Jing,et al."ALYREF links 3-end processing to nuclear export of non-polyadenylated mRNAs".EMBO JOURNAL 38.9(2019):16.

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来源：大连化学物理研究所

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