pH-Regulated Heterostructure Porous Particles Enable Similarly Sized Protein Separation
文献类型：期刊论文
| 作者 | Song, Yongyang1,3; Fan, Jun-Bing1; Li, Xiuling2; Liang, Xinmiao2; Wang, Shutao1,3 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2019-04-19 |
| 卷号 | 31期号:16页码:8 |
| 关键词 | double emulsion heterostructure porous particles interfacial polymerization pH-regulated protein separation |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201900391 |
| 通讯作者 | Wang, Shutao(stwang@mail.ipc.ac.cn) |
| 英文摘要 | Porous particles are frequently used for various healthcare applications that involve protein separation processes. However, conventional porous particles, either homogeneous particles or those subjected to surface modification with a layer of specific molecules, often encounter bottlenecks in separating proteins with similar size. Here, it is reported that heterostructure-enabled separation particles (HESP), synthesized by a double emulsion interfacial polymerization process, can effectively and rapidly separate similarly sized proteins. Double emulsion interfacial polymerization endows the HESP with a nanoscale carboxylic layer outside the particles and inside the pores, allowing pH-regulated selective adsorption of proteins. Thus, by optimizing the environmental pH, proteins with similar size can be effectively and rapidly separated. These HESP are expected to show potential in widespread applications ranging from biomolecule adsorption, encapsulation, and separation to controlled release and other biomedical fields. |
| WOS关键词 | BICINCHONINIC ACID ; PURIFICATION ; BINDING ; IDENTIFICATION ; CHROMATOGRAPHY ; NANOPARTICLES ; POLYSTYRENE ; BIOMARKERS ; SURFACES ; NANODOTS |
| 资助项目 | National Key R&D Program of China[2018YFC1105301] ; National Natural Science Foundation of China[21425314] ; National Natural Science Foundation of China[21872158] ; National Natural Science Foundation of China[21421061] ; National Program for Special Support of Eminent Professionals |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000468005400027 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Program for Special Support of Eminent Professionals ; National Program for Special Support of Eminent Professionals ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Program for Special Support of Eminent Professionals ; National Program for Special Support of Eminent Professionals ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Program for Special Support of Eminent Professionals ; National Program for Special Support of Eminent Professionals ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Program for Special Support of Eminent Professionals ; National Program for Special Support of Eminent Professionals |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171857]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Wang, Shutao |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, CAS Ctr Excellence Nanosci, CAS Key Lab Bioinspired Mat & Interfacial Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Yongyang,Fan, Jun-Bing,Li, Xiuling,et al. pH-Regulated Heterostructure Porous Particles Enable Similarly Sized Protein Separation[J]. ADVANCED MATERIALS,2019,31(16):8. |
| APA | Song, Yongyang,Fan, Jun-Bing,Li, Xiuling,Liang, Xinmiao,&Wang, Shutao.(2019).pH-Regulated Heterostructure Porous Particles Enable Similarly Sized Protein Separation.ADVANCED MATERIALS,31(16),8. |
| MLA | Song, Yongyang,et al."pH-Regulated Heterostructure Porous Particles Enable Similarly Sized Protein Separation".ADVANCED MATERIALS 31.16(2019):8. |
入库方式： OAI收割
来源：大连化学物理研究所
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