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Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling

文献类型：期刊论文

作者Zhou, Ye1,2; Liu, Zheyi1; Zhang, Jinbao3; Dou, Tongyi1; Chen, Jin1; Ge, Guangbo1,4; Zhu, Shujia3; Wang, Fangjun1
刊名CHEMICAL COMMUNICATIONS
出版日期2019-04-18
卷号55期号:30页码:4311-4314
ISSN号1359-7345
DOI10.1039/c9cc00520j
通讯作者Zhu, Shujia(shujiazhu@ion.ac.cn) ; Wang, Fangjun(wangfj@dicp.ac.cn)
英文摘要Herein we provide a mass spectrometry-based lysine reactivity profiling strategy to monitor the ligand modulation of protein receptors, which is achieved by active dimethyl labeling of lysine residues and comparison of the alterations of labeling reactivity during ligand binding. The small-molecule ligand modulation patterns on the catechol-Omethyltransferase and the N-methyl-D-aspartate receptors have been predicted, including both binding regions and related conformational changes.
WOS关键词NMDA RECEPTOR ; ALLOSTERIC MODULATORS ; MOLECULAR-MECHANISMS ; MASS-SPECTROMETRY ; METHYLATION ; IDENTIFICATION ; SUBUNIT ; GLYCINE ; ENZYMES ; BINDING
资助项目National Key R&D Program of China[2016YFF0200504] ; National Natural Science Foundation of China[91853101] ; National Natural Science Foundation of China[21675152] ; DICP[ZZBS201603] ; Shanghai Rising-Star Program[17QA1404800]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000467979900037
出版者ROYAL SOC CHEMISTRY
资助机构National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program
源URL[http://cas-ir.dicp.ac.cn/handle/321008/171907]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Zhu, Shujia; Wang, Fangjun
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Ye,Liu, Zheyi,Zhang, Jinbao,et al. Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling[J]. CHEMICAL COMMUNICATIONS,2019,55(30):4311-4314.
APA Zhou, Ye.,Liu, Zheyi.,Zhang, Jinbao.,Dou, Tongyi.,Chen, Jin.,...&Wang, Fangjun.(2019).Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling.CHEMICAL COMMUNICATIONS,55(30),4311-4314.
MLA Zhou, Ye,et al."Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling".CHEMICAL COMMUNICATIONS 55.30(2019):4311-4314.

入库方式： OAI收割

来源：大连化学物理研究所

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