Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway
文献类型：期刊论文
| 作者 | Xu, Chunyan1; Han, Yang1; Zhang, Lin1; Yu, Xiao2; Wang, Shidan1; Yin, Heng3; Wang, Shujing1 |
| 刊名 | CELL DEATH & DISEASE
 |
| 出版日期 | 2019-05-10 |
| 卷号 | 10页码:14 |
| ISSN号 | 2041-4889 |
| DOI | 10.1038/s41419-019-1560-y |
| 通讯作者 | Yin, Heng(yinheng@dicp.ac.cn) ; Wang, Shujing(wangshujing@dlmedu.edu.cn) |
| 英文摘要 | Chitosan oligosaccharides have been reported to inhibit various tumors. However, the water-soluble marine plant oligosaccharide alginate oligosaccharide (AOS) has only rarely been reported to have anti-cancer effects. Moreover, the inhibitory effect of AOS on prostate cancer and the underlying molecular mechanism remain unknown. This study shows that AOS inhibited cell growth, which was consistent with the attenuation of alpha 2,6-sialylation modification. Furthermore, AOS inhibited ST6Gal-1 promoter activity and thus affected transcriptional processes. In addition, AOS could activate the Hippo/YAP pathway and block the recruitment of both the coactivator YAP and c-Jun. Furthermore, YAP interacted with the transcription factor c-Jun and regulated the transcriptional activity of the downstream target ST6Gal-1 gene. Consistent with in vitro data, AOS suppressed the tumorigenicity of prostate cancer cells via the Hippo/YAP pathway in vivo. In summary, these data indicate that AOS slows the proliferation of prostate cancer and provides a basis for the healthy function of kelp in traditional cognition. |
| WOS关键词 | BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE ; C-JUN ; ENDOPLASMIC-RETICULUM ; COLON-CANCER ; SIALYLATION ; EXPRESSION ; INVASION ; ADHESION ; GLYCANS ; DEATH |
| 资助项目 | National Natural Science Foundation of China[31470799] ; Natural Science Foundation of Liaoning Province[20170540288] ; Special Fund of Dalian city for Distinguished Young Scholars[2017RJ07] ; National Key R&D Program of China[2017YF0200900] ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000468671400001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/171933]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Yin, Heng; Wang, Shujing |
| 作者单位 | 1.Dalian Med Univ, Coll Basic Med Sci, Inst Glycobiol, Dept Biochem & Mol Biol, Dalian, Liaoning, Peoples R China 2.Dalian Med Univ, Coll Basic Med Sci, Dept Pathol, Dalian, Liaoning, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Chunyan,Han, Yang,Zhang, Lin,et al. Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway[J]. CELL DEATH & DISEASE,2019,10:14. |
| APA | Xu, Chunyan.,Han, Yang.,Zhang, Lin.,Yu, Xiao.,Wang, Shidan.,...&Wang, Shujing.(2019).Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway.CELL DEATH & DISEASE,10,14. |
| MLA | Xu, Chunyan,et al."Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway".CELL DEATH & DISEASE 10(2019):14. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。