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Impacts of lung and tumor volumes on lung dosimetry for nonsmall cell lung cancer

文献类型：期刊论文

作者Lei, Weijie1,2,3,4; Jia, Jing2,3; Cao, Ruifen2,3; Song, Jing2,3; Hu, Liqin1,2,3
刊名JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
出版日期2017-09-01
卷号18期号:5页码:22-28
关键词lung cancer intensity-modulated radiotherapy volumetric-modulated arc therapy
ISSN号1526-9914
DOI10.1002/acm2.12104
通讯作者Hu, Liqin(Liqin.hu@fds.org.cn)
英文摘要The purpose of this study was to determine the impacts of lung and tumor volumes on normal lung dosimetry in three-dimensional conformal radiotherapy (3DCRT), step-and-shoot intensity-modulated radiotherapy (ssIMRT), and single full-arc volumetric-modulated arc therapy (VMAT) in treatment of nonsmall cell lung cancers (NSCLC). All plans were designed to deliver a total dose of 66 Gy in 33 fractions to PTV for the 32 NSCLC patients with various total (bilateral) lung volumes, planning target volumes (PTVs), and PTV locations. The ratio of the lung volume (total lung volume excluding the PTV volume) to the PTV volume (LTR) was evaluated to represent the impacts in three steps. (a) The least squares method was used to fit mean lung doses (MLDs) to PTVs or LTRs with power-law function in the population cohort (N = 32). (b) The population cohort was divided into three groups by LTRs based on first step and then by PTVs, respectively. The MLDs were compared among the three techniques in each LTR group (LG) and each PTV group (PG). (c) The power-law correlation was tested by using the adaptive radiation therapy (ART) planning data of individual patients in the individual cohort (N = 4). Different curves of power-law function with high R-2 values were observed between averaged LTRs and averaged MLDs for 3DCRT, ssIMRT, and VMAT, respectively. In the individual cohort, high R-2 values of fitting curves were also observed in individual patients in ART, although the trend was highly patient-specific. There was a more obvious correlation between LTR and MLD than that between PTV and MLD.
WOS关键词INTENSITY-MODULATED RADIOTHERAPY ; RADIATION-THERAPY ; STEREOTACTIC RADIOTHERAPY ; OUTCOMES ; TRIAL ; RISK
资助项目National Natural Science Foundation of China (NSFC)[11605233] ; Chinese Academy of Sciences Foundation[YZJJ201618] ; Natural Science Foundation of Anhui Province[1508085QH180] ; Industrialization Fund
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000410651600004
出版者WILEY
资助机构National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Chinese Academy of Sciences Foundation ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; 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源URL[http://ir.hfcas.ac.cn:8080/handle/334002/35805]  
专题合肥物质科学研究院_中国科学院核能安全技术研究所
通讯作者Hu, Liqin
作者单位1.Univ Sci & Technol China, Hefei, Anhui, Peoples R China
2.Chinese Acad Sci, Key Lab Neutron & Radiat Safety, Inst Nucl Energy Safety Technol, Hefei, Anhui, Peoples R China
3.Engn Technol Res Ctr Accurate Radiotherapy Anhui, Hefei, Anhui, Peoples R China
4.Xuzhou Med Univ, Affiliated Hosp 2, Xuzhou, Peoples R China
推荐引用方式
GB/T 7714		 Lei, Weijie,Jia, Jing,Cao, Ruifen,et al. Impacts of lung and tumor volumes on lung dosimetry for nonsmall cell lung cancer[J]. JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS,2017,18(5):22-28.
APA Lei, Weijie,Jia, Jing,Cao, Ruifen,Song, Jing,&Hu, Liqin.(2017).Impacts of lung and tumor volumes on lung dosimetry for nonsmall cell lung cancer.JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS,18(5),22-28.
MLA Lei, Weijie,et al."Impacts of lung and tumor volumes on lung dosimetry for nonsmall cell lung cancer".JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS 18.5(2017):22-28.

入库方式： OAI收割

来源：合肥物质科学研究院

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