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GCH1 plays a role in the high-altitude adaptation of Tibetans

文献类型：期刊论文

作者Zheng WS2,3; Zhang XM3; Zhang H3; He YX3,5,10; Guo YB2,3,10; qixuebin@mail.kiz.ac.cn; sub@mail.kiz.ac.cn; Baimakangzhuo4; Su B*3; Ouzhuluobu4
刊名Zoological Research
出版日期2017
卷号38期号:3页码:155-162
关键词Gch1 Positive Selection Tibetan Hypoxia Adaptation Nitric Oxide Hemoglobin Oxygen Saturation
英文摘要Tibetans are well adapted to high-altitude hypoxia. Previous genome-wide scans have reported many candidate genes for this adaptation, but only a few have been studied. Here we report on a hypoxia gene (GCH1, GTP-cyclohydrolase I), involved in maintaining nitric oxide synthetase (NOS) function and normal blood pressure, that harbors many potentially adaptive variants in Tibetans. We resequenced an 80.8 kb fragment covering the entire gene region of GCH1 in 50 unrelated Tibetans. Combined with previously published data, we demonstrated many GCH1 variants showing deep divergence between highlander Tibetans and lowlander Han Chinese. Neutrality tests confirmed a signal of positive Darwinian selection on GCH1 in Tibetans. Moreover, association analysis indicated that the Tibetan version ofGCH1 was significantly associated with multiple physiological traits in Tibetans, including blood nitric oxide concentration, blood oxygen saturation, and hemoglobin concentration. Taken together, we propose that GCH1 plays a role in the genetic adaptation of Tibetans to high altitude hypoxia.
语种英语
资助机构This study was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13010000), the National Natural Science Foundation of China (91631306 to BS, 31671329 to XQ, 31460287 to Ou., 31501013 to HZ and 31360032 to CC), the National 973 program (2012CB518202 to TW), the State Key Laboratory of Genetic Resources and Evolution (GREKF15-05, GREKF16-04), and the Zhufeng Scholar Program of Tibetan University ; This study was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13010000), the National Natural Science Foundation of China (91631306 to BS, 31671329 to XQ, 31460287 to Ou., 31501013 to HZ and 31360032 to CC), the National 973 program (2012CB518202 to TW), the State Key Laboratory of Genetic Resources and Evolution (GREKF15-05, GREKF16-04), and the Zhufeng Scholar Program of Tibetan University ; This study was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13010000), the National Natural Science Foundation of China (91631306 to BS, 31671329 to XQ, 31460287 to Ou., 31501013 to HZ and 31360032 to CC), the National 973 program (2012CB518202 to TW), the State Key Laboratory of Genetic Resources and Evolution (GREKF15-05, GREKF16-04), and the Zhufeng Scholar Program of Tibetan University ; This study was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13010000), the National Natural Science Foundation of China (91631306 to BS, 31671329 to XQ, 31460287 to Ou., 31501013 to HZ and 31360032 to CC), the National 973 program (2012CB518202 to TW), the State Key Laboratory of Genetic Resources and Evolution (GREKF15-05, GREKF16-04), and the Zhufeng Scholar Program of Tibetan University
源URL[http://159.226.149.26:8080/handle/152453/11736]  
专题昆明动物研究所_遗传资源与进化国家重点实验室
昆明动物研究所_比较基因组学
通讯作者qixuebin@mail.kiz.ac.cn; sub@mail.kiz.ac.cn
作者单位1.School of Life Science and Technology, Shanghai Tech University, Shanghai 200031, China
2.College of Animal Science and Technology, Gansu Agricultural University, Lanzhou Gansu 730070, China
3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China
4.High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China
5.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming Yunnan 650204, China
6.Chinese Academy of Sciences Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology(PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
7.Center for Computational Genomics, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
8.Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China
9.National Key Laboratory of High Altitude Medicine, High Altitude Medical Research Institute, Xining Qinghai 810012, China
10.Authors contributed equally to this work
推荐引用方式
GB/T 7714		 Zheng WS,Zhang XM,Zhang H,et al. GCH1 plays a role in the high-altitude adaptation of Tibetans[J]. Zoological Research,2017,38(3):155-162.
APA Zheng WS.,Zhang XM.,Zhang H.,He YX.,Guo YB.,...&Xu SH.(2017).GCH1 plays a role in the high-altitude adaptation of Tibetans.Zoological Research,38(3),155-162.
MLA Zheng WS,et al."GCH1 plays a role in the high-altitude adaptation of Tibetans".Zoological Research 38.3(2017):155-162.

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来源：昆明动物研究所

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