中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 昆明动物研究所
  3. 昆明动物研究所
  4. 遗传资源与进化国家重点实验室
EP300 contributes to high-altitude adaptation in Tibetans by regulating nitric oxide production

文献类型：期刊论文

作者Xu SH1,8,9; Zheng WS2,3,10; He YX3,5,10; Peng Y3; Zhang H3; Zhang XM3; Guo YB2,3; Chen H6; Cui CY4,10; Zhao SG2
刊名Zoological Research
出版日期2017
卷号38期号:3页码:163-170
关键词Tibetans High Altitude Hypoxia Ep300 Genetic Adaptation Nitric Oxide
英文摘要The genetic adaptation of Tibetans to high altitude hypoxia likely involves a group of genes in the hypoxic pathway, as suggested by earlier studies. To test the adaptive role of the previously reported candidate gene EP300 (histone acetyltransferase p300), we conducted resequencing of a 108.9 kb gene region of EP300 in 80 unrelated Tibetans. The allele-frequency and haplotype-based neutrality tests detected signals of positive Darwinian selection on EP300 in Tibetans, with a group of variants showing allelic divergence between Tibetans and lowland reference populations, including Han Chinese, Europeans, and Africans. Functional prediction suggested the involvement of multiple EP300 variants in gene expression regulation. More importantly, genetic association tests in 226 Tibetans indicated significant correlation of the adaptive EP300 variants with blood nitric oxide (NO) concentration. Collectively, we propose that EP300 harbors adaptive variants in Tibetans, which might contribute to high-altitude adaptation through regulating NO production.
语种英语
资助机构This study was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13010000), the National Natural Science Foundation of China (91631306 to BS, 31671329 to XQ, 31460287 to Ou, 31501013 to HZ, and 31360032 to CC), the National 973 program (2012CB518202 to TW), the State Key Laboratory of Genetic Resources and Evolution (GREKF15-05, GREKF16-04), and the Zhufeng Scholar Program of Tibetan University ; This study was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13010000), the National Natural Science Foundation of China (91631306 to BS, 31671329 to XQ, 31460287 to Ou, 31501013 to HZ, and 31360032 to CC), the National 973 program (2012CB518202 to TW), the State Key Laboratory of Genetic Resources and Evolution (GREKF15-05, GREKF16-04), and the Zhufeng Scholar Program of Tibetan University ; This study was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13010000), the National Natural Science Foundation of China (91631306 to BS, 31671329 to XQ, 31460287 to Ou, 31501013 to HZ, and 31360032 to CC), the National 973 program (2012CB518202 to TW), the State Key Laboratory of Genetic Resources and Evolution (GREKF15-05, GREKF16-04), and the Zhufeng Scholar Program of Tibetan University ; This study was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13010000), the National Natural Science Foundation of China (91631306 to BS, 31671329 to XQ, 31460287 to Ou, 31501013 to HZ, and 31360032 to CC), the National 973 program (2012CB518202 to TW), the State Key Laboratory of Genetic Resources and Evolution (GREKF15-05, GREKF16-04), and the Zhufeng Scholar Program of Tibetan University
源URL[http://159.226.149.26:8080/handle/152453/11737]  
专题昆明动物研究所_遗传资源与进化国家重点实验室
昆明动物研究所_比较基因组学
通讯作者sub@mail.kiz.ac.cn; qixuebin@mail.kiz.ac.cn
作者单位1.Chinese Academy of Sciences Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
2.College of Animal Science and Technology, Gansu Agricultural University, Lanzhou Gansu 730070, China
3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China
4.High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China;
5.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming Yunnan 650204, Chin
6.Center for Computational Genomics, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
7.National Key Laboratory of High Altitude Medicine, High Altitude Medical Research Institute, Xining Qinghai 810012, China
8.School of Life Science and Technology, Shanghai Tech University, Shanghai 200031, China
9.Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China
10.Authors contributed equally to this work
推荐引用方式
GB/T 7714		 Xu SH,Zheng WS,He YX,et al. EP300 contributes to high-altitude adaptation in Tibetans by regulating nitric oxide production[J]. Zoological Research,2017,38(3):163-170.
APA Xu SH.,Zheng WS.,He YX.,Peng Y.,Zhang H.,...&qixuebin@mail.kiz.ac.cn.(2017).EP300 contributes to high-altitude adaptation in Tibetans by regulating nitric oxide production.Zoological Research,38(3),163-170.
MLA Xu SH,et al."EP300 contributes to high-altitude adaptation in Tibetans by regulating nitric oxide production".Zoological Research 38.3(2017):163-170.

入库方式： OAI收割

来源：昆明动物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。