Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in Rhesus macaque brain
文献类型：期刊论文
| 作者 | Xu KY8,9; yizhang@ablife.cc; Tian RR2,9; Zhang BW2,6; Li JL*5,9; Wang XT*3,6; Zhang Yi*1,7; Yang LM9; Liu SL2,8,9; Wang ZB2,9 |
| 刊名 | Genome Research
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:published online |
| 英文摘要 | Long noncoding RNA (lncRNA)-mediated epigenetic regulation plays important roles in wide range of biological processes and diseases. Here, we applied comprehensive analyses of RNA-seq and CAGE-seq (cap analysis of gene expression and sequencing) to characterize the dynamic changes in lncRNA expression in rhesus macaque brain in four age groups from postnatal to aged periods. We identified 18 anatomically diverse lncRNA modules and 14 mRNA modules representing spatial, age and sex specificities. Spatiotemporal- and sex-biased changes in lncRNA expression are in general higher than that observed in mRNA expression. A negative correlation between lncRNA and mRNA expression in cerebral cortex was observed, such relationship was further explored and functionally validated. Our findings offer an initial insight into spatial-, age- and sex-biased changes in lncRNA expression in macaque brain, and that the distinct classification of such changes might represent a previously unappreciated regulatory system which potentially contributes to brain development and ageing. |
| 语种 | 英语 |
| 资助机构 | This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). |
| 源URL | [http://159.226.149.26:8080/handle/152453/11822]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_分子免疫药理学 昆明动物研究所_神经系统编码 昆明动物研究所_表观遗传与神经退行性疾病 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 通讯作者 | yizhang@ablife.cc |
| 作者单位 | 1.Laboratory for Genome Regulation and Human Health, ABLife Inc., Wuhan 430075, P. R. China 2.These authors contributed equally to this work 3.CAS Center for Excellence in Molecular Cell Science, China 4.CAS Center for Excellence in Brain Science and Intelligence Technology, China 5.Kunming Primate Research Center of the Chinese Academy of Sciences Kunming, Yunnan 650223, China 6.School of Life science, CAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Science, University of Science and Technology of China, Hefei ， Anhui 230026, China 7.Center for Genome Analysis, ABLife Inc., Wuhan 430075, P. R. China 8.Kunming College of Life Science, University of Chinese Academy of Sciences Kunming 650223, China 9.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology, the Chinese Academy of Sciences Kunming, Yunnan, 650223, China |
| 推荐引用方式 GB/T 7714 | Xu KY,yizhang@ablife.cc,Tian RR,et al. Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in Rhesus macaque brain[J]. Genome Research,2017,**(**):published online. |
| APA | Xu KY.,yizhang@ablife.cc.,Tian RR.,Zhang BW.,Li JL*.,...&Lv LB.(2017).Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in Rhesus macaque brain.Genome Research,**(**),published online. |
| MLA | Xu KY,et al."Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in Rhesus macaque brain".Genome Research **.**(2017):published online. |
入库方式： OAI收割
来源：昆明动物研究所
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