α3-Deletion Isoform of HLA-A11 Modulates Cytotoxicity of NK Cells: Correlations with HIV-1 Infection of Cells
文献类型：期刊论文
| 作者 | Zhang XH2,3; Zheng YT*2; Dai ZX2; Zheng HY1,2; Chen X2,3; zhengyt@mail.kiz.ac.cn; Lian XD2,3 |
| 刊名 | Journal of Immunology
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:Epub ahead of print |
| 英文摘要 | Alternative splicing occurs frequently in many genes, especially those involved in immunity. Unfortunately, the functions of many alternatively spliced molecules from immunologically relevant genes remain unknown. Classical HLA-I molecules are expressed on almost all nucleated cells and play a pivotal role in both innate and adaptive immunity. Although splice variants of HLA-I genes have been reported, the details of their functions have not been reported. In the current study, we determined the characteristics, expression, and function of a novel splice variant of HLA-A11 named HLA-A11svE4 HLA-A11svE4 is located on the cell surface without β2-microglobulin (β2m). Additionally, HLA-A11svE4 forms homodimers as well as heterodimers with HLA-A open conformers, instead of combining with β2m. Moreover, HLA-A11svE4 inhibits the activation of NK cells to protect target cells. Compared with β2m and HLA-A11, the heterodimer of HLA-A11svE4 and HLA-A11 protected target cells from lysis by NK cells more effectively. Furthermore, HLA-AsvE4 expression was upregulated by HIV-1 in vivo and by HSV, CMV, and hepatitis B virus in vitro. In addition, our findings indicated that HLA-A11svE4 molecules were functional in activating CD8+ T cells through Ag presentation. Taken together, these results suggested that HLA-A11svE4 can homodimerize and form a novel heterodimeric complex with HLA-A11 open conformers. Furthermore, the data are consistent with HLA-A11svE4 playing a role in the immune escape of HIV-1. |
| 语种 | 英语 |
| 资助机构 | This work was supported by the National Natural Science Foundation of China (Grants 81373124, 81471620, 81671627, U1604287, and 30872317), the Knowl- edge Innovation Program of the Chinese Academy of Sciences (Grant KJZD-EW- L10-02), and the Key Scientific and Technological Program of China (Grant 2016YFC1201000). ; This work was supported by the National Natural Science Foundation of China (Grants 81373124, 81471620, 81671627, U1604287, and 30872317), the Knowl- edge Innovation Program of the Chinese Academy of Sciences (Grant KJZD-EW- L10-02), and the Key Scientific and Technological Program of China (Grant 2016YFC1201000). ; This work was supported by the National Natural Science Foundation of China (Grants 81373124, 81471620, 81671627, U1604287, and 30872317), the Knowl- edge Innovation Program of the Chinese Academy of Sciences (Grant KJZD-EW- L10-02), and the Key Scientific and Technological Program of China (Grant 2016YFC1201000). ; This work was supported by the National Natural Science Foundation of China (Grants 81373124, 81471620, 81671627, U1604287, and 30872317), the Knowl- edge Innovation Program of the Chinese Academy of Sciences (Grant KJZD-EW- L10-02), and the Key Scientific and Technological Program of China (Grant 2016YFC1201000). |
| 源URL | [http://159.226.149.26:8080/handle/152453/12014]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_分子免疫药理学 |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 作者单位 | 1.School of Life Sciences, Uni- versity of Science and Technology of China, Hefei 230026, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China |
| 推荐引用方式 GB/T 7714 | Zhang XH,Zheng YT*,Dai ZX,et al. α3-Deletion Isoform of HLA-A11 Modulates Cytotoxicity of NK Cells: Correlations with HIV-1 Infection of Cells[J]. Journal of Immunology,2017,**(**):Epub ahead of print. |
| APA | Zhang XH.,Zheng YT*.,Dai ZX.,Zheng HY.,Chen X.,...&Lian XD.(2017).α3-Deletion Isoform of HLA-A11 Modulates Cytotoxicity of NK Cells: Correlations with HIV-1 Infection of Cells.Journal of Immunology,**(**),Epub ahead of print. |
| MLA | Zhang XH,et al."α3-Deletion Isoform of HLA-A11 Modulates Cytotoxicity of NK Cells: Correlations with HIV-1 Infection of Cells".Journal of Immunology **.**(2017):Epub ahead of print. |
入库方式： OAI收割
来源：昆明动物研究所
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