Oral microbial community assembly under the influence of periodontitis
文献类型：期刊论文
| 作者 | samma@uidaho.edu; Yi B5; Zou Q1; Dai L3; Ma ZS*4; Yang XH2; Peng ST3,4; Chen HJ4,5 |
| 刊名 | Plos One
 |
| 出版日期 | 2017 |
| 卷号 | 23期号:8页码:e0182259 |
| 英文摘要 | Several ecological hypotheses (e.g., specific plaque, non-specific plaque and keystone pathogen) regarding the etiology of periodontitis have been proposed since the 1990s, most of which have been centered on the concept of dysbiosis associated with periodontitis. Nevertheless, none of the existing hypotheses have presented mechanistic interpretations on how and why dysbiosis actually occurs. Hubbell's neutral theory of biodiversity offers a powerful null model to test hypothesis regarding the mechanism of community assembly and diversity maintenance from the metagenomic sequencing data, which can help to understand the forces that shape the community dynamics such as dysbiosis. Here we reanalyze the dataset from Abusleme et al.'s comparative study of the oral microbial communities from periodontitis patients and healthy individuals. Our study demonstrates that 14 out of 61 communities (23%) passed the neutrality test, a percentage significantly higher than the previous reported neutrality rate of 1% in human microbiome (Li & Ma 2016, Scientific Reports). This suggests that, while the niche selection may play a predominant role in the assembly and diversity maintenance in oral microbiome, the effect of neutral dynamics may not be ignored. However, no statistically significant differences in the neutrality passing rates were detected between the periodontitis and healthy treatments with Fisher's exact probability test and multiple testing corrections, suggesting that the mechanism of community assembly is robust against disturbances such as periodontitis. In addition, our study confirmed previous finding that periodontitis patients exhibited higher biodiversity. These findings suggest that while periodontitis may significantly change the community composition measured by diversity (i.e., the exhibition or 'phenotype' of community assembly), it does not seem to cause the 'mutation' of the 'genotype" (mechanism) of community assembly. We argue that the 'phenotypic' changes explain the observed link (not necessarily causal) between periodontitis and community dysbiosis, which is certainly worthy of further investigation. |
| 语种 | 英语 |
| 资助机构 | National Natural Science Foundation of China(No. 71473243),Open Grants from the StateKey Laboratory of Genetic Resources and Evolution (No.GREKF16-11,No.GREKF17-11),an International Cooperative Grantanda Key Project of Biomedicine and Health from Yunnan Province, China. ; National Natural Science Foundation of China(No. 71473243),Open Grants from the StateKey Laboratory of Genetic Resources and Evolution (No.GREKF16-11,No.GREKF17-11),an International Cooperative Grantanda Key Project of Biomedicine and Health from Yunnan Province, China. ; National Natural Science Foundation of China(No. 71473243),Open Grants from the StateKey Laboratory of Genetic Resources and Evolution (No.GREKF16-11,No.GREKF17-11),an International Cooperative Grantanda Key Project of Biomedicine and Health from Yunnan Province, China. ; National Natural Science Foundation of China(No. 71473243),Open Grants from the StateKey Laboratory of Genetic Resources and Evolution (No.GREKF16-11,No.GREKF17-11),an International Cooperative Grantanda Key Project of Biomedicine and Health from Yunnan Province, China. |
| 源URL | [http://159.226.149.26:8080/handle/152453/12025]  |
| 专题 | 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_计算生物与生物信息学 |
| 通讯作者 | samma@uidaho.edu |
| 作者单位 | 1.Department of Computer Science, Tianjin University, Tianjin China 2.Oral Medicine Department, Yan’an Hospital of Kunming City, Kunming, Yunnan, China 3.Faculty of Science, Kunming University of Science and Technology, Kunming, China 4.omputational Biology and Medical Ecology Lab, State Key Lab of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academyof Sciences, Kunming, China 5.College of Mathematics, Honghe University, Mengzi, Yunnan Province, China |
| 推荐引用方式 GB/T 7714 | samma@uidaho.edu,Yi B,Zou Q,et al. Oral microbial community assembly under the influence of periodontitis[J]. Plos One,2017,23(8):e0182259. |
| APA | samma@uidaho.edu.,Yi B.,Zou Q.,Dai L.,Ma ZS*.,...&Chen HJ.(2017).Oral microbial community assembly under the influence of periodontitis.Plos One,23(8),e0182259. |
| MLA | samma@uidaho.edu,et al."Oral microbial community assembly under the influence of periodontitis".Plos One 23.8(2017):e0182259. |
入库方式： OAI收割
来源：昆明动物研究所
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