ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus
文献类型：期刊论文
| 作者 | Ma PC*1; Kong QH1; Ma BY*1; Yang XC1,3; Sun B3,4; Liu XL1,3; kunmapch@mail.kiz.ac.cn; Ren BY1,2; mao@mail.kiz.ac.cn; Li CC1 |
| 刊名 | Open Biology
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:X页码:e170122. |
| 关键词 | Smad Smurf Zc4h2 Bone Morphogenesis Protein Signalling Neural Development |
| 英文摘要 | Bone morphogenetic proteins (BMPs) play vital roles in regulating stem cell maintenance, differentiation and embryonic development. Intracellularly, BMP signalling is mediated by Smad proteins, which are regulated post-transcriptionally through reversible phosphorylation and ubiquitination. ZC4H2 is a small nuclear protein associated with intellectual disability and neural development in humans. Here, we report that ZC4H2 is highly expressed in the developing neural system and is involved in neural patterning and BMP signalling in Xenopus Knockdown of ZC4H2 led to expansion of the expression of the pan neural plate marker Sox2 in Xenopusembryos. In mammalian cells, ZC4H2 promotes BMP signalling and is involved in BMP regulated myogenic and osteogenic differentiation of mouse myoblast cells. Mechanistically, ZC4H2 binds and stabilizes Smad1 and Smad5 proteins through reducing their association with the Smurf ubiquitin ligases and thus their ubiquitination. We also found that a group of ZC4H2 mutations, which have been isolated in patients with intellectual disorders, showed weaker Smad-stabilizing activity, suggesting that the ZC4H2-Smad interaction might contribute to proper neural development in humans. |
| 语种 | 中文 |
| 资助机构 | This work was supported by grants from The West Light Foundation of The Chinese Academy of Sciences, NSFC-Yunnan Joint Funds (U1302226) and Yunnan Applied Basic Research Project (No. 2016FB043). ; This work was supported by grants from The West Light Foundation of The Chinese Academy of Sciences, NSFC-Yunnan Joint Funds (U1302226) and Yunnan Applied Basic Research Project (No. 2016FB043). ; This work was supported by grants from The West Light Foundation of The Chinese Academy of Sciences, NSFC-Yunnan Joint Funds (U1302226) and Yunnan Applied Basic Research Project (No. 2016FB043). ; This work was supported by grants from The West Light Foundation of The Chinese Academy of Sciences, NSFC-Yunnan Joint Funds (U1302226) and Yunnan Applied Basic Research Project (No. 2016FB043). |
| 源URL | [http://159.226.149.26:8080/handle/152453/12027]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_发育生物学 |
| 通讯作者 | kunmapch@mail.kiz.ac.cn; mao@mail.kiz.ac.cn |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People’s Republic of China 2.Institute of Health Sciences, Anhui University, Hefei 230601, People’s Republic of China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650203, People’s Republic of China 4.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650223, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Ma PC*,Kong QH,Ma BY*,et al. ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus[J]. Open Biology,2017,7(X):e170122.. |
| APA | Ma PC*.,Kong QH.,Ma BY*.,Yang XC.,Sun B.,...&Li CC.(2017).ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus.Open Biology,7(X),e170122.. |
| MLA | Ma PC*,et al."ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus".Open Biology 7.X(2017):e170122.. |
入库方式： OAI收割
来源：昆明动物研究所
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