Establishment of basal cell carcinoma animal model in Chinese tree shrew (Tupaia belangeri chinensis)
文献类型：期刊论文
| 作者 | Shen QS1,2; Yang CP*1,2; Chen YB*1,2; ybchen@mail.kiz.ac.cn; cuipingyang@mail.kiz.ac.cn; Jiang LP1,2 |
| 刊名 | Zoological Research
 |
| 出版日期 | 2017 |
| 卷号 | 38期号:4页码:180-190 |
| 关键词 | Basal Cell Carcinoma Chinese Tree Shrew Hedgehog |
| 英文摘要 | Basal cell carcinoma (BCC) is the most common skin cancer worldwide, with incidence rates continuing to increase. Ultraviolet radiation is the major environmental risk factor and dysregulation of the Hedgehog (Hh) signaling pathway has been identified in most BCCs. The treatment of locally advanced and metastatic BBCs is still a challenge and requires a better animal model than the widely used rodents for drug development and testing. Chinese tree shrews (Tupaia belangeri chinensis) are closely related to primates, bearing many physiological and biochemical advantages over rodents for characterizing human diseases. Here, we successfully established a Chinese tree shrew BCC model by infecting tail skins with lentiviral SmoA1, an active form of Smoothened (Smo) used to constitutively activate the Hh signaling pathway. The pathological characteristics were verified by immunohistochemical analysis. Interestingly, BCC progress was greatly enhanced by the combined usage of lentiviral SmoA1 and shRNA targeting Chinese tree shrew p53. This work provides a useful animal model for further BCC studies and future drug discoveries. |
| 语种 | 英语 |
| 资助机构 | This study was supported by the National Key Research and Development Program of China (2016YFA0100900), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13000000), the National Nature Science Foundation of China (U1502224, 81672764), and the Yunnan Applied Basic Research Projects (2014FA038, 2016FA009, 2014FB182). C.P.Y was also supported by the Chinese Academy of Sciences Western Light Program, Youth Innovation Promotion Association, CAS ; This study was supported by the National Key Research and Development Program of China (2016YFA0100900), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13000000), the National Nature Science Foundation of China (U1502224, 81672764), and the Yunnan Applied Basic Research Projects (2014FA038, 2016FA009, 2014FB182). C.P.Y was also supported by the Chinese Academy of Sciences Western Light Program, Youth Innovation Promotion Association, CAS ; This study was supported by the National Key Research and Development Program of China (2016YFA0100900), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13000000), the National Nature Science Foundation of China (U1502224, 81672764), and the Yunnan Applied Basic Research Projects (2014FA038, 2016FA009, 2014FB182). C.P.Y was also supported by the Chinese Academy of Sciences Western Light Program, Youth Innovation Promotion Association, CAS ; This study was supported by the National Key Research and Development Program of China (2016YFA0100900), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13000000), the National Nature Science Foundation of China (U1502224, 81672764), and the Yunnan Applied Basic Research Projects (2014FA038, 2016FA009, 2014FB182). C.P.Y was also supported by the Chinese Academy of Sciences Western Light Program, Youth Innovation Promotion Association, CAS |
| 源URL | [http://159.226.149.26:8080/handle/152453/12031]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_肿瘤信号转导 |
| 通讯作者 | ybchen@mail.kiz.ac.cn; cuipingyang@mail.kiz.ac.cn |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming Yunnan 650204, China |
| 推荐引用方式 GB/T 7714 | Shen QS,Yang CP*,Chen YB*,et al. Establishment of basal cell carcinoma animal model in Chinese tree shrew (Tupaia belangeri chinensis)[J]. Zoological Research,2017,38(4):180-190. |
| APA | Shen QS,Yang CP*,Chen YB*,ybchen@mail.kiz.ac.cn,cuipingyang@mail.kiz.ac.cn,&Jiang LP.(2017).Establishment of basal cell carcinoma animal model in Chinese tree shrew (Tupaia belangeri chinensis).Zoological Research,38(4),180-190. |
| MLA | Shen QS,et al."Establishment of basal cell carcinoma animal model in Chinese tree shrew (Tupaia belangeri chinensis)".Zoological Research 38.4(2017):180-190. |
入库方式： OAI收割
来源：昆明动物研究所
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