Hippocampal Administration of Levothyroxine Impairs Contextual Fear Memory Consolidation in Rats
文献类型：期刊论文
| 作者 | Yang YX4; Jiang ZH4,5; Zhou H3,4; Xu L*4; Yu DF1,4; Zhou QX4; Ma RR*4; Zou L2; Jiang Y1; Wu XQ6 |
| 刊名 | frontiers in Cellular Neuroscience
 |
| 出版日期 | 2017 |
| 卷号 | 11期号:X页码:e223 |
| 关键词 | Acquisition Consolidation Fear Memory Hippocampus Levothyroxine Retrieval |
| DOI | lxu@vip.163.com;talktomaomao@163.com |
| 英文摘要 | Thyroid hormone (TH) receptors are highly distributed in the hippocampus, which plays a vital role in memory processes. However, how THs are involved in the different stages of memory process is little known. Herein, we used hippocampus dependent contextual fear conditioning to address the effects of hippocampal THs on the different stages of fear memory. First, we found that a single systemic levothyroxine (LT4) administration increased the level of free triiodothyronine (FT3) and free tetraiodothyroxine (FT4) not only in serum but also in hippocampus. In addition, a single systemic LT4 administration immediately after fear conditioning significantly impaired fear memory. These results indicated the important role of hippocampal THs in fear memory process. To further confirm the effects of hippocampal THs on the different stages of fear memory, LT4 (0.4 μg/μl, 1 μl/side) was injected bilaterally into hippocampus. Rats given LT4 into hippocampus before training or tests had no effect on the acquisition or retrieval of fear memory, however rats given LT4 into hippocampus either immediately or 2 h after training showed being significantly impaired fear memory, which demonstrated LT4 administration into hippocampus impairs the consolidation but has no effect on the acquisition and retrieval of fear memory. Furthermore, hippocampal injection of LT4 did not affect rats' locomotor activity, thigmotaxis and THs level in prefrontal cortex (PFC) and serum. These findings may have important implications for understanding mechanisms underlying contribution of THs to memory disorders. |
| 语种 | 英语 |
| 资助机构 | This work was supported by National Basic Research of China (2013CB835100 and 2015CB553502), Strategic Priority Research Program of Chinese Academy of Sciences (XDB02020002), National Science Foundation of China (81460216, 31371141 and U150222),ScienceandTechnologyProgramofYunnanProvince (2013GA003 and 2010ZC208), Youth Innovation Promotion Association of Chinese Academy of Sciences (2013250), Natural Scientific Research fund (#508 in 2011) of the Chinese Human Resources and Social Security Department. ; This work was supported by National Basic Research of China (2013CB835100 and 2015CB553502), Strategic Priority Research Program of Chinese Academy of Sciences (XDB02020002), National Science Foundation of China (81460216, 31371141 and U150222),ScienceandTechnologyProgramofYunnanProvince (2013GA003 and 2010ZC208), Youth Innovation Promotion Association of Chinese Academy of Sciences (2013250), Natural Scientific Research fund (#508 in 2011) of the Chinese Human Resources and Social Security Department. |
| 源URL | [http://159.226.149.26:8080/handle/152453/12032]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Department of Nuclear Medicine, First People’s Hospital of Yunnan Province, Kunming, China 2.Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 3.School of Life Sciences, University of Science and Technology of China, Hefei, China 4.Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 5.Department of Neuropsychopathy, Clinical Medical School, Dali University, Dali, China 6.Respiratory Department, First People’s Hospital of Yunnan Province, Kunming, China |
| 推荐引用方式 GB/T 7714 | Yang YX,Jiang ZH,Zhou H,et al. Hippocampal Administration of Levothyroxine Impairs Contextual Fear Memory Consolidation in Rats[J]. frontiers in Cellular Neuroscience,2017,11(X):e223. |
| APA | Yang YX.,Jiang ZH.,Zhou H.,Xu L*.,Yu DF.,...&Wu XQ.(2017).Hippocampal Administration of Levothyroxine Impairs Contextual Fear Memory Consolidation in Rats.frontiers in Cellular Neuroscience,11(X),e223. |
| MLA | Yang YX,et al."Hippocampal Administration of Levothyroxine Impairs Contextual Fear Memory Consolidation in Rats".frontiers in Cellular Neuroscience 11.X(2017):e223. |
入库方式： OAI收割
来源：昆明动物研究所
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