Lycoplanine A, a C 16 N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium complanatum
文献类型：期刊论文
| 作者 | Zhu QF2,3; Yang J*1; Wu XD2; Nian Y1; qinshizhao@mail.kib.ac.cn; Su J2; Li XN2; Zhang ZJ2,3; Zhao QS*2 |
| 刊名 | Organic Letters
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:published online |
| 英文摘要 | Lycoplanine A (1), a Lycopodium alkaloid with a 6/9/5 tricyclic ring skeleton fused with the γ-lactone ring and featuring an unusual 1-oxa-6-azaspiro[4.4]nonane moiety and an unprecedented 3-azabicyclo[6.3.1]dodecane unit, was isolated from the club moss Lycopodium complanatum. The structure and absolute configuration of 1 were identified by a combination of NMR spectroscopic analysis and single-crystal X-ray diffraction. Biological studies showed that 1 is a potent Cav3.1 T-type calcium channel (TTCC) inhibitor with an IC50 value of 6.06 μM. |
| 语种 | 英语 |
| 资助机构 | This work was financially supported by the National Natural Science Foundation of China (U0932602 and U1502223), the National Basic Research Program of China (973 Program) (2011CB915503), the Foundation of the Chinese Academy of Sciences (ZSTH-019), and the Yunnan Major Science and Technology Project (2015ZJ002). ; This work was financially supported by the National Natural Science Foundation of China (U0932602 and U1502223), the National Basic Research Program of China (973 Program) (2011CB915503), the Foundation of the Chinese Academy of Sciences (ZSTH-019), and the Yunnan Major Science and Technology Project (2015ZJ002). ; This work was financially supported by the National Natural Science Foundation of China (U0932602 and U1502223), the National Basic Research Program of China (973 Program) (2011CB915503), the Foundation of the Chinese Academy of Sciences (ZSTH-019), and the Yunnan Major Science and Technology Project (2015ZJ002). ; This work was financially supported by the National Natural Science Foundation of China (U0932602 and U1502223), the National Basic Research Program of China (973 Program) (2011CB915503), the Foundation of the Chinese Academy of Sciences (ZSTH-019), and the Yunnan Major Science and Technology Project (2015ZJ002). |
| 源URL | [http://159.226.149.26:8080/handle/152453/12033]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_离子通道药物研发中心 |
| 通讯作者 | qinshizhao@mail.kib.ac.cn |
| 作者单位 | 1.Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People’s Republic of China 2.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China 3.University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Zhu QF,Yang J*,Wu XD,et al. Lycoplanine A, a C 16 N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium complanatum[J]. Organic Letters,2017,**(**):published online. |
| APA | Zhu QF.,Yang J*.,Wu XD.,Nian Y.,qinshizhao@mail.kib.ac.cn.,...&Zhao QS*.(2017).Lycoplanine A, a C 16 N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium complanatum.Organic Letters,**(**),published online. |
| MLA | Zhu QF,et al."Lycoplanine A, a C 16 N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium complanatum".Organic Letters **.**(2017):published online. |
入库方式： OAI收割
来源：昆明动物研究所
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