Rapid Evolution of Genes Involved in Learning and Energy Metabolism for Domestication of the Laboratory Rat
文献类型：期刊论文
| 作者 | Liu HQ3; Wang MS3; Yao YG1; Li HP6; Su LY1,4; Zhang YP*3; wudongdong@mail.kiz.ac.cn; zhangyp@mail.kiz.ac.cn; Su YH2; Zeng L3,4 |
| 刊名 | Molecular Biology and Evolution
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:Epub ahead of print |
| 关键词 | Artificial Selection Domestication LaboRatory Rat Origin |
| 英文摘要 | The laboratory rat, widely used in biomedical research, is domesticated from wild brown rat. The origin and genetic mechanism underlying domestication of the laboratory rat remain largely elusive. In the present study, large scale genomes supported a single origin for the laboratory rat, possibly from a sister group to wild rats from Europe/Africa/Middle East. Genomic and transcriptomic analyses uncovered many artificially selected genes (e.g. FOXP2, B3GAT1, and CLOCK) involved in the nervous system. These genes associate with learning ability and regulation of circadian rhythm, which likely enabled the successful domestication of the laboratory rat. Particularly, many genes, including mitochondrial genes responsible for energy metabolism, displayed a substantially increased expression in the brain of laboratory rats compared to wild rats. Our findings demystify the origin and evolution of this model animal, and provide insight into the process of its domestication. |
| 资助机构 | This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (grant no. XDB13020600), and the National Natural Science Foundation of China (91731304). ; This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (grant no. XDB13020600), and the National Natural Science Foundation of China (91731304). ; This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (grant no. XDB13020600), and the National Natural Science Foundation of China (91731304). ; This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (grant no. XDB13020600), and the National Natural Science Foundation of China (91731304). |
| 源URL | [http://159.226.149.26:8080/handle/152453/12047]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子进化基因组学 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_进化与发育转录组学 |
| 通讯作者 | wudongdong@mail.kiz.ac.cn; zhangyp@mail.kiz.ac.cn |
| 作者单位 | 1.KeyLaboratoryofAnimalModelsandHumanDiseaseMechanismsoftheChineseAcademyofSciences& YunnanProvince,Kunming Institute of Zoology, Kunming, China 2.College of Animal Science and Technology, Yunnan Agricultural University, Kunming, China 3.State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 4.University of Chinese Academy of Sciences, Beijing, China 5.State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan, Yunnan University, Kunming, China 6.CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China |
| 推荐引用方式 GB/T 7714 | Liu HQ,Wang MS,Yao YG,et al. Rapid Evolution of Genes Involved in Learning and Energy Metabolism for Domestication of the Laboratory Rat[J]. Molecular Biology and Evolution,2017,**(**):Epub ahead of print. |
| APA | Liu HQ.,Wang MS.,Yao YG.,Li HP.,Su LY.,...&Li Y.(2017).Rapid Evolution of Genes Involved in Learning and Energy Metabolism for Domestication of the Laboratory Rat.Molecular Biology and Evolution,**(**),Epub ahead of print. |
| MLA | Liu HQ,et al."Rapid Evolution of Genes Involved in Learning and Energy Metabolism for Domestication of the Laboratory Rat".Molecular Biology and Evolution **.**(2017):Epub ahead of print. |
入库方式： OAI收割
来源：昆明动物研究所
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