The African Zika Virus MR-766 is More Virulent and Causes More Severe Brain Damage than Current Asian Lineage and Dengue Virus
文献类型：期刊论文
| 作者 | Qi XP2; Stice SL5; Jianfu@usc.edu; Shao Q3; Herrlinger S4; Zhu YN4; Chen JF*3; Brindley MA1; Yang M3; Goodfellow F5 |
| 刊名 | Development
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:Epub ahead of print |
| 关键词 | African Zikv (Mr-766) Asian Zikv Brain Damage Denv2 Neuronal Death |
| 英文摘要 | The Zika virus (ZIKV) has two lineages, Asian and African, and their impact on developing brains has not been compared. Dengue virus (DENV) is a close family member of ZIKV and co-circulates with ZIKV. Here we performed intracerebral inoculation of embryonic mouse brains with dengue virus 2 (DENV2), and found that DENV2 is sufficient to cause smaller brain size due to increased cell death in neural progenitor cells (NPCs) and neurons. Compared to the currently circulating Asian lineage of ZIKV (MEX1-44), DENV2 grows slower, causes less neuronal death, and fails to cause postnatal animal death. Surprisingly, our side-by-side comparison uncovered that African ZIKV isolate (MR-766) is more potent in causing brain damage and postnatal lethality than MEX1-44. In comparison to MEX1-44, MR-766 grows faster in NPCs and in the developing brain, and causes more pronounced cell death in NPCs and neurons, resulting in more severe neuronal loss. Together, these results reveal that DENV2 is sufficient to cause smaller brain sizes, and suggest that the ZIKV African lineage is more virulent and causes more severe brain damage than the Asian lineage. |
| 语种 | 英语 |
| 资助机构 | Zika and Dengue virus isolates were provided by the World Reference Center for Emerging Viruses and Arboviruses at UTMB. Chen lab is supported by funds from R00HD073269 (J.C.), R01NS097231 (J.C.), R01NS096176 from the National Institute of Health. ; Zika and Dengue virus isolates were provided by the World Reference Center for Emerging Viruses and Arboviruses at UTMB. Chen lab is supported by funds from R00HD073269 (J.C.), R01NS097231 (J.C.), R01NS096176 from the National Institute of Health. ; Zika and Dengue virus isolates were provided by the World Reference Center for Emerging Viruses and Arboviruses at UTMB. Chen lab is supported by funds from R00HD073269 (J.C.), R01NS097231 (J.C.), R01NS096176 from the National Institute of Health. ; Zika and Dengue virus isolates were provided by the World Reference Center for Emerging Viruses and Arboviruses at UTMB. Chen lab is supported by funds from R00HD073269 (J.C.), R01NS097231 (J.C.), R01NS096176 from the National Institute of Health. |
| 源URL | [http://159.226.149.26:8080/handle/152453/12051]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_病原菌感染与宿主免疫机制 |
| 通讯作者 | Jianfu@usc.edu |
| 作者单位 | 1.Department of Infectious Diseases, Department of Population Health and Center for Vaccines and Immunology, University of Georgia, Athens, GA, 30602, USA 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033 4.Department of Genetics, Department of Biochemistry & Molecular Biology, University of Georgia, Athens, GA, 30602, USA 5.Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA |
| 推荐引用方式 GB/T 7714 | Qi XP,Stice SL,Jianfu@usc.edu,et al. The African Zika Virus MR-766 is More Virulent and Causes More Severe Brain Damage than Current Asian Lineage and Dengue Virus[J]. Development,2017,**(**):Epub ahead of print. |
| APA | Qi XP.,Stice SL.,Jianfu@usc.edu.,Shao Q.,Herrlinger S.,...&Goodfellow F.(2017).The African Zika Virus MR-766 is More Virulent and Causes More Severe Brain Damage than Current Asian Lineage and Dengue Virus.Development,**(**),Epub ahead of print. |
| MLA | Qi XP,et al."The African Zika Virus MR-766 is More Virulent and Causes More Severe Brain Damage than Current Asian Lineage and Dengue Virus".Development **.**(2017):Epub ahead of print. |
入库方式： OAI收割
来源：昆明动物研究所
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