Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla
文献类型：期刊论文
| 作者 | Wei X1,7; Guo Y1,7; Chen YB6; Wang YF*5; Luo XD*3,4; Khan A2; Zhao YL1; wangyifen@mail.kib.ac.cn; Liu YP1; Wang B1,7 |
| 刊名 | Nat. Prod. Bioprospect.
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:published online |
| 关键词 | Indole Alkaloids Nscs Proliferation Uncaria Rhynchophylla |
| 英文摘要 | Uncaria rhynchophylla is commonly recognized as a traditional treatment for dizziness, cerebrovascular diseases, and nervous disorders in China. Previously, the neuro-protective activities of the alkaloids from U. rhynchophylla were intensively reported. In current work, three new indole alkaloids (1-3), identified as geissoschizic acid (1), geissoschizic acid N 4-oxide (2), and 3β-sitsirikine N 4-oxide (3), as well as 26 known analogues were isolated from U. rhynchophylla. However, in the neural stem cells (NSCs) proliferation assay for all isolated compounds, geissoschizic acid (1), geissoschizic acid N 4-oxide (2), isocorynoxeine (6), isorhynchophylline (7), (4S)-akuammigine N-oxide (8), and (4S)-rhynchophylline N-oxide (10) showed unexpected inhibitory activities at 10 μM. Unlike previous neuro-protective reports, as a warning or caution, our finding showcased a clue for possible NSCs toxicity and the neural lesions risk of U. rhynchophylla, while the structure-activity relationships of the isolated compounds were discussed also. |
| 语种 | 英语 |
| 资助机构 | The authors are grateful to the National Natural Science Foundation of China (81225024, 31500292, 31770388) for financial support. ; The authors are grateful to the National Natural Science Foundation of China (81225024, 31500292, 31770388) for financial support. ; The authors are grateful to the National Natural Science Foundation of China (81225024, 31500292, 31770388) for financial support. ; The authors are grateful to the National Natural Science Foundation of China (81225024, 31500292, 31770388) for financial support. |
| 源URL | [http://159.226.149.26:8080/handle/152453/12055]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_肿瘤信号转导 |
| 通讯作者 | wangyifen@mail.kib.ac.cn; xdluo@mail.kib.ac.cn |
| 作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of Chin 2.Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan 3.Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, People's Republic of China 4.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China 5.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China 6.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, People's Republic of China 7.University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China |
| 推荐引用方式 GB/T 7714 | Wei X,Guo Y,Chen YB,et al. Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla[J]. Nat. Prod. Bioprospect.,2017,**(**):published online. |
| APA | Wei X.,Guo Y.,Chen YB.,Wang YF*.,Luo XD*.,...&Jiang LP.(2017).Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.Nat. Prod. Bioprospect.,**(**),published online. |
| MLA | Wei X,et al."Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla".Nat. Prod. Bioprospect. **.**(2017):published online. |
入库方式： OAI收割
来源：昆明动物研究所
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