DAT1 methylation is associated with methylphenidate response on oppositional and hyperactive-impulsive symptoms in children and adolescents with ADHD
文献类型：期刊论文
| 作者 | Liu RX1; Yang JZ5; Shao JR3; Ding KJ1; kangbao98@163.com; Kang CY*1; Wen JF*3; Yang RX1; Liu H1; Qian QJ4 |
| 刊名 | THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
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| 出版日期 | 2017 |
| 卷号 | 18期号:4页码:291–299 |
| 关键词 | Attention Deficit Hyperactivity Disorder Dna Methylation Dopamine Transporter Gene (Dat1/ Slc6a3) Dopamine Receptor D4 Gene (drD4) Methylphenidate Efficacy |
| 英文摘要 | Objectives: To examine the association of the DNA methylation of DAT1 and DRD4 gene with methylphenidate (MPH) response in attention deficit hyperactivity disorder (ADHD).Methods: One hundred and eleven DSM-IV defined ADHD Chinese Han children were recruited. Inattention, hyperactivity–impulsivity and oppositional symptoms were evaluated by the Swanson, Nolan and Pelham–IV–parent rating scale (SNAP-IV-P) at baseline and 6 weeks after MPH treatment. DNA methylation of CpG sites in the promoter sequences of DAT1 and DRD4 was examined for association with treatment response.Results: Greater improvement on the SNAP-IV-P total score and percentage change from baseline score were both significantly correlated with DAT1 methylation (rho =−0.222, P = .019 and rho = −0.203, P = .032, respectively). A secondary analysis demonstrated that the effect of DAT1 methylation on symptom response was primarily related to the percentage change in oppositional symptoms (rho = −0.242; P = .012), with a smaller significant effect on hyperactivity–impulsivity (rho = −0.192; P = .045). No significant correlation was found between the treatment effect on inattention and DAT1 methylation (rho = −0.101; P = .292). No significant correlation was observed between mean DRD4 methylation and measures of treatment outcome or baseline symptoms.Conclusions: Our findings provide initial evidence for the involvement of the epigenetic alterations of DAT1 in modulating the response to MPH treatment in ADHD, primarily on oppositional and hyperactive-impulsive symptoms. |
| 语种 | 英语 |
| 资助机构 | National Natural Science Foundation of China [30900488, 81460218]. National Key Technology Research and Development Program of the Ministry of Science and Technology of China [2015BAI13B01]. ; National Natural Science Foundation of China [30900488, 81460218]. National Key Technology Research and Development Program of the Ministry of Science and Technology of China [2015BAI13B01]. ; National Natural Science Foundation of China [30900488, 81460218]. National Key Technology Research and Development Program of the Ministry of Science and Technology of China [2015BAI13B01]. ; National Natural Science Foundation of China [30900488, 81460218]. National Key Technology Research and Development Program of the Ministry of Science and Technology of China [2015BAI13B01]. |
| 源URL | [http://159.226.149.26:8080/handle/152453/12070]  |
| 专题 | 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_真核细胞进化基因组 |
| 通讯作者 | kangbao98@163.com |
| 作者单位 | 1.Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, PR China 2.BMRC, Sheffield Hallam University, Howard Street, Sheffield, UK 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), Kunming, Yunnan, PR China 4.National Clinical Research Centre for Mental Disorders, Peking University Sixth Hospital, Beijing, PR China 5.Department of Psychiatry, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, PR China |
| 推荐引用方式 GB/T 7714 | Liu RX,Yang JZ,Shao JR,et al. DAT1 methylation is associated with methylphenidate response on oppositional and hyperactive-impulsive symptoms in children and adolescents with ADHD[J]. THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,2017,18(4):291–299. |
| APA | Liu RX.,Yang JZ.,Shao JR.,Ding KJ.,kangbao98@163.com.,...&Chen B.(2017).DAT1 methylation is associated with methylphenidate response on oppositional and hyperactive-impulsive symptoms in children and adolescents with ADHD.THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,18(4),291–299. |
| MLA | Liu RX,et al."DAT1 methylation is associated with methylphenidate response on oppositional and hyperactive-impulsive symptoms in children and adolescents with ADHD".THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY 18.4(2017):291–299. |
入库方式： OAI收割
来源：昆明动物研究所
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