Identification of the major histocompatibility complex class-II DM and DO alleles in a cohort of northern pig-tailed macaques (Macaca leonina)
文献类型：期刊论文
| 作者 | zhengyt@mail.kiz.ac.cn; Lian XD1,2; Zheng YT*1,3; Dai ZX1; Zhang XH1,2 |
| 刊名 | Immunogenetic
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:published online |
| 关键词 | Northernpig-tailedmacaque Macacaleonina Mhc-dm Mhc-do |
| 英文摘要 | The northern pig-tailed macaque (Macaca leonina) has been considered as an independent species from the pig-tailed macaque group. We have previously reported that this species macaque has the potential to be a useful animal model in HIV/AIDS pathogenesis and vaccine studies due to its susceptibility to HIV-1. To develop this animal into a potential HIV/AIDS model, we have studied the classical MHC genes of this animal. In this study, the non-classical MHC genes Malo-DM and Malo-DO alleles were first characterized by sequencing and cloning in 12 unrelated northern pig-tailed macaques. A total of 20 full-length sequences identified include 4 Malo-DMA, 5 Malo-DMB, 7 Malo-DOA, and 4 Malo-DOB alleles. Most of these allele sequences were shared between northern pig-tailed macaque and other macaque species in exon 2. The full-length MHC-DM and MHC-DO sequences provide more comprehensive analysis of immunogenetics of northern pig-tailed macaques and increase the value of the macaques in further biomedical studies. |
| 语种 | 英语 |
| 资助机构 | This work was supported by the Key Scientific and Technological Program of China (2017ZX10304402-002), the National Basic Research Program of China (2012CBA01305), the National Natural Science Foundation of China (81373124, 81671627, 81172876, 81471620, 81571606), the Knowledge Innovation Program of CAS (ZDRW-ZS-2016-4-2), and the Natural Science Foundation of Yunnan Province (2014FB181, P0120150150). ; This work was supported by the Key Scientific and Technological Program of China (2017ZX10304402-002), the National Basic Research Program of China (2012CBA01305), the National Natural Science Foundation of China (81373124, 81671627, 81172876, 81471620, 81571606), the Knowledge Innovation Program of CAS (ZDRW-ZS-2016-4-2), and the Natural Science Foundation of Yunnan Province (2014FB181, P0120150150). ; This work was supported by the Key Scientific and Technological Program of China (2017ZX10304402-002), the National Basic Research Program of China (2012CBA01305), the National Natural Science Foundation of China (81373124, 81671627, 81172876, 81471620, 81571606), the Knowledge Innovation Program of CAS (ZDRW-ZS-2016-4-2), and the Natural Science Foundation of Yunnan Province (2014FB181, P0120150150). ; This work was supported by the Key Scientific and Technological Program of China (2017ZX10304402-002), the National Basic Research Program of China (2012CBA01305), the National Natural Science Foundation of China (81373124, 81671627, 81172876, 81471620, 81571606), the Knowledge Innovation Program of CAS (ZDRW-ZS-2016-4-2), and the Natural Science Foundation of Yunnan Province (2014FB181, P0120150150). |
| 源URL | [http://159.226.149.26:8080/handle/152453/12076]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_分子免疫药理学 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 作者单位 | 1.Key Laboratory ofAnimal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive PeptidesofYunnanProvince,KunmingInstituteofZoology,Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.University of Chinese Academy of Sciences, Beijing 100049, China 3.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | zhengyt@mail.kiz.ac.cn,Lian XD,Zheng YT*,et al. Identification of the major histocompatibility complex class-II DM and DO alleles in a cohort of northern pig-tailed macaques (Macaca leonina)[J]. Immunogenetic,2017,**(**):published online. |
| APA | zhengyt@mail.kiz.ac.cn,Lian XD,Zheng YT*,Dai ZX,&Zhang XH.(2017).Identification of the major histocompatibility complex class-II DM and DO alleles in a cohort of northern pig-tailed macaques (Macaca leonina).Immunogenetic,**(**),published online. |
| MLA | zhengyt@mail.kiz.ac.cn,et al."Identification of the major histocompatibility complex class-II DM and DO alleles in a cohort of northern pig-tailed macaques (Macaca leonina)".Immunogenetic **.**(2017):published online. |
入库方式： OAI收割
来源：昆明动物研究所
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