Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites
文献类型：期刊论文
| 作者 | Liu YH16,17; Li Y2; Guo XM2; Zhang YP*15,16,17; Wang GD*15,16; Qi XP*2; Xu T2; Peng MS15,16; Gilbert M.T.P3,4,10; Adeola AC15,16 |
| 刊名 | Molecular Biology and Evolution
 |
| 出版日期 | 2017 |
| 卷号 | **期号:***页码:Accepted |
| 关键词 | African Dogs Adaptive Evolution Anti-parasite Demographic History |
| 其他题名 | qixiaopeng@mail.kiz.ac.cn, wanggd@mail.kiz.ac.cn and |
| 英文摘要 | Natural selection in domestic dogs is of great interest in evolutionary biology since dogs have migrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored their demographic history and genetic basis of adaptation to the tropical African environment using whole genome analyses of 19 African indigenous dogs from Nigeria. Demographic analysis suggests that the ancestors of these dogs migrated into Africa from Eurasia 14,000 years ago and underwent a severe founder effect before population expansion. Admixture analysis further reveals that African dog genomes contain about 1.88%-3.50% introgression from African golden wolves (Canis anthus). Population genetic analysis identifies 50 positively selected genes linked with immunity, angiogenesis, ultraviolet protection, as well as insulin secretion and sensitivity that may contribute to adaptation to tropical conditions. One of the positively selected genes, ADGRE1 (adhesion G protein-coupled receptor E1), has also been found to be association with severe malaria resistance in African human populations. Functional assessments showed that ADGRE1 provides protective host defense against Plasmodium infections. This result, together with the fact that the inflammatory response to canine babesiosis is similar to complicated falciparum malaria in humans, support the dogs as a model for the study of malaria control and treatment. |
| 语种 | 英语 |
| 资助机构 | This work was supported by grants from the NSFC (91531303), and the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000),the Chinese Academy of Sciences (CXJJ-17-M141) and (Y602381081), Sino-Africa Joint Research Center, Chinese Academy of Sciences (SAJC201611). ERC Consolidator Grant (681396) ‘Extinction Genomics’, Marie Skłodowska-Curie Actions Fellowship (655732) ‘Wherewolf’ and Carlsbergfondet Fellowship (CF14-0995). G-D W and M-S P are supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences. N.O.O. is supported by the CAS-TWAS President's Fellowship Program for Doctoral Candidates. CF acknowledges support from Fundação para a Ciência e Tecnologia (FCT, MCTES, Portugal) and Faculdade de Ciências da Universidade de Lisboa through, respectively, the Ciência 2007 contract C2007-UL-342-CBA1 and the contract as Invited Assistant Professor. ; This work was supported by grants from the NSFC (91531303), and the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000),the Chinese Academy of Sciences (CXJJ-17-M141) and (Y602381081), Sino-Africa Joint Research Center, Chinese Academy of Sciences (SAJC201611). ERC Consolidator Grant (681396) ‘Extinction Genomics’, Marie Skłodowska-Curie Actions Fellowship (655732) ‘Wherewolf’ and Carlsbergfondet Fellowship (CF14-0995). G-D W and M-S P are supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences. N.O.O. is supported by the CAS-TWAS President's Fellowship Program for Doctoral Candidates. CF acknowledges support from Fundação para a Ciência e Tecnologia (FCT, MCTES, Portugal) and Faculdade de Ciências da Universidade de Lisboa through, respectively, the Ciência 2007 contract C2007-UL-342-CBA1 and the contract as Invited Assistant Professor. |
| 源URL | [http://159.226.149.26:8080/handle/152453/12088]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子进化基因组学 昆明动物研究所_脑疾病灵长类动物模型联合实验室 |
| 作者单位 | 1.Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China 3.CE3C – Centre for Ecology, Evolution and Environmental Changes, Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal 4.Natural History Museum, University of Oslo, PO Box 1172 Blindern, N-0318 Oslo, Norway 5.Department of Veterinary Medicine, University of Ibadan, Nigeria 6.Taraba State Ministry of Agriculture and Natural Resources, Jalingo, Taraba State, Nigeria 7.Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031, China 8.Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672, Singapore 9.Sino-Africa Joint Research Center, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China 10.NTNU University Museum, N-7491 Trondheim, Norway |
| 推荐引用方式 GB/T 7714 | Liu YH,Li Y,Guo XM,et al. Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites[J]. Molecular Biology and Evolution,2017,**(***):Accepted. |
| APA | Liu YH.,Li Y.,Guo XM.,Zhang YP*.,Wang GD*.,...&Wang L.(2017).Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites.Molecular Biology and Evolution,**(***),Accepted. |
| MLA | Liu YH,et al."Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites".Molecular Biology and Evolution **.***(2017):Accepted. |
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来源：昆明动物研究所
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