Antitumor aporphine alkaloids from Thalictrum wangii
文献类型：期刊论文
| 作者 | Afsar Khan1; Xu-Dong Zhao3; Ying Sun6; Yun-Li Zhao4; Dong Yang3,5; Xiao-Dong Luo2,4; Qiong Jin2,4; Bei Wang4,5; Xin Wei4,5; Yi-Fen Wang4 |
| 刊名 | Fitoterapia
 |
| 出版日期 | 2018 |
| 期号 | 128页码:204–212 |
| 关键词 | Thalictrum Wangii Aporphine Alkaloids Antitumor Glioma Stem Cells |
| DOI | 10.1016/j.fitote.2018.05.012 |
| 英文摘要 | Nine new isoquinoline alkaloids, including two proaporphine (1–2), three aporphine (3–5), two oxoaporphine(6–7), and two seco-bisbenzylisoquinoline (8–9), together with three known alkaloids (10−12) were isolatedfrom the whole plant of Thalictrum wangii. Their structures were established on the basis of spectroscopic data.The antitumor activities of the isolated compounds were evaluated in vitro against glioma stem cells. Compounds3–8 showed the cytotoxicity with IC 50 values 15–20 μg/mL. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/12264]  |
| 专题 | 昆明动物研究所_肿瘤干细胞生物学 |
| 通讯作者 | Xu-Dong Zhao; Ya-Ping Liu |
| 作者单位 | 1.Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan 2.Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, PR China 4.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences/Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, PR China 5.University of Chinese Academy of Sciences, Beijing 100049, PR China 6.School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China |
| 推荐引用方式 GB/T 7714 | Afsar Khan,Xu-Dong Zhao,Ying Sun,et al. Antitumor aporphine alkaloids from Thalictrum wangii[J]. Fitoterapia,2018(128):204–212. |
| APA | Afsar Khan.,Xu-Dong Zhao.,Ying Sun.,Yun-Li Zhao.,Dong Yang.,...&Ya-Ping Liu.(2018).Antitumor aporphine alkaloids from Thalictrum wangii.Fitoterapia(128),204–212. |
| MLA | Afsar Khan,et al."Antitumor aporphine alkaloids from Thalictrum wangii".Fitoterapia .128(2018):204–212. |
入库方式： OAI收割
来源：昆明动物研究所
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