Gamma band oscillation (GBO) and sensorygating (SG) are associated with many cognitive functions.Ketamine induces deficits of GBO and SG in the prefrontalcortex (PFC). However, the time-courses of the effects ofdifferent doses of ketamine on GBO power and SG arepoorly understood. Studies have indicated that GBO powerand SG have a common substrate for their generation andabnormalities. In this study, we found that (1) ketamineadministration increased GBO power in the PFC in ratsdifferently in the low- and high-dose groups; (2) auditorySG was significantly lower than baseline in the 30 mg/kgand 60 mg/kg groups, but not in the 15 mg/kg and 120 mg/kg groups; and (3) changes in SG and basal GBO powerwere significantly correlated in awake rats. These resultsindicate a relationship between mechanisms underlyingauditory SG and GBO power.