Recent genome-wide association studies (GWAS) have identified multiple risk loci that showstrong associations with schizophrenia. However, pinpointing the potential causal genes atthe reported loci remains a major challenge. Here we identify candidate causal genes forschizophrenia using an integrative genomic approach. Sherlock integrative analysis shows thatALMS1, GLT8D1, and CSNK2B are schizophrenia risk genes, which are validated using inde-pendent brain expression quantitative trait loci (eQTL) data and integrative analysis method(SMR). Consistently, gene expression analysis in schizophrenia cases and controls furthersupports the potential role of these three genes in the pathogenesis of schizophrenia. Finally,we show that GLT8D1 and CSNK2B knockdown promote the proliferation and inhibit thedifferentiation abilities of neural stem cells, and alter morphology and synaptic transmissionof neurons. These convergent lines of evidence suggest that the ALMS1, CSNK2B, and GLT8D1genes may be involved in pathophysiology of schizophrenia.