Establishing the quantitative relation between electron spin resonance (ESR) signal intensity and quartz mass can help both to improve ESR signal measurement and to allow a greater understanding of the characteristics of ESR color centers. However, this relation has not as yet been clearly defined. We measured the ESR signal intensities in the Ge and E' centers in the pure quartz in our samples. We applied both standard and additional doses of irradiation by using two different types of spectrometers across different timeframes in an attempt to establish the quantitative relation between the ESR signal intensities in Ge and E' centers and quartz mass. The linear correlation established between ESR signal intensity and quartz mass was significant for the samples treated with additional irradiation, but there was, overall, no close correlation between ESR signal intensity and quartz mass for samples which were not given additional irradiation doses. A significant correlation between ESR signal intensity and quartz masses of weight >= 0.35 g was established for Ge center, but this was not the case for quartz masses of weight <= 0.3 g. This would suggest that the apparent instability of Ge center is likely aroused by the application of weak signals. The quantitative relation between ESR signal intensity and quartz mass might therefore provide a possible solution for the correction of signal intensities in aliquots of unequal weight in laboratory measurements, particularly for non-irradiated aliquots on the dose growth curve. We would propose that larger quartz masses be used for the clear identification of Ge center signal, for enhancing ESR signal intensity, and for improving the quality of signal measurement.