The India-Asia collision and subsequent subduction initiated the evolution of major tectonic features in the Western Syntaxis. The complex tectonic structure and shallow to deep seismicity have attracted geoscientists over the past two decades. The present research is based on a 3D tomographic inversion of P-wave arrival time data to constrain the crustal and upper mantle structure beneath the NW Himalayas and Pamir-Hindukush region using the Double-difference tomography. We utilized a very large multi-scale dataset comprising 19,080 earthquakes recorded at 397 local and regional seismic stations from 1950 to 2017. The northward dipping seismic zone coinciding with the low velocity anomaly suggests the subduction of the Indian lower crust beneath the Hindukush. The extent of the northward advancing Indian slab increases from east to west in this region. We observed no signs of northward subduction of the Indian plate under the Hindukush beyond 71 degrees longitude. The Indian plate overturns due south after interacting with the Asian plate beneath the southern Pamir, which correlates with the counter-clockwise rotation of the Indian plate. The Asian plate is also imaged as a southward subducting seismic zone beneath the southern Pamir. In the NW Himalayas, the northward subducting Indian plate appears as a gently dipping low velocity anomaly beneath the Karakoram Block. The stresses caused by the collision and subduction along the Shyok Suture and Indus Suture are translated to the south. The crustal scale seismicity and high velocity anomalies indicate an intense deformation in the crust, which is manifested by syntaxial bends and thrust faults to the south of the Main Mantle Thrust.