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Spatial pattern and variations in the prevalence of congenital heart disease in children aged 4-18 years in the Qinghai-Tibetan Plateau

文献类型：期刊论文

作者Ma, Li-Guang1,4; Chen, Qiu-Hong2; Wang, Yuan-Yuan1; Wang, Jing5; Ren, Zhou-Peng3; Cao, Zong-Fu1; Cao, Yan-Rong4; Ma, Xu1,6; Wang, Bin-Bin1,6
刊名SCIENCE OF THE TOTAL ENVIRONMENT
出版日期2018-06-15
卷号627页码:158-165
关键词Congenital heart disease Qinghai-Tibetan Plateau Spatial pattern and distribution Environmental risk factor
ISSN号0048-9697
DOI10.1016/j.scitotenv.2018.01.194
通讯作者Chen, Qiu-Hong(chqh666@aliyun.com) ; Ma, Xu(nicgr@263.net) ; Wang, Bin-Bin(wbbahu@163.com)
英文摘要Purpose: This study aimed to investigate the spatial distribution pattern of the prevalence of congenital heart disease (CHD) in children in Qinghai-Tibetan Plateau (QTP), a high-altitude region in China. Methods: Epidemiological data from a survey on the prevalence of CHD in Qinghai Province including 288,066 children (4-18 years) were used in this study. The prevalence and distribution pattern of CHD was determined by sex, CHD subtype, and nationality and altitude. Spatial pattern analysis using Getis-Ord Gi* was used to identify the spatial distribution of CHD. Bayesian spatial binomial regression was performed to examine the relationship between the prevalence of CHD and environmental risk factors in the QTP. Results: The prevalence of CHD showed a significant spatial clustering pattern. The Tibetan autonomous prefecture of Yushu (average altitude > 4000 m) and the Mongolian autonomous county of Henan (average altitude > 3600 m) in Huangnan had the highest prevalence of CHD. Univariate analysis showed that with ascending altitude, the total prevalence of CHD, that in girls and boys with CHD, and that of the subtypes PDA and ASD increasing accordingly. Thus, environmental factors greatly contributed to the prevalence of CHD. Conclusions: The prevalence of CHD shows significant spatial clustering pattern in the QTP. The CHD subtype prevalence clustering pattern has statistical regularity which would provide convenient clues of environmental risk factors. Our results may provide support to make strategies of CHD prevention, to reduce the incidence of CHD in high altitude regions of China. (C) 2018 Published by Elsevier B.V.
WOS关键词HIGH-ALTITUDE ADAPTATION ; RISK-FACTORS ; DEFECTS ; EPIDEMIOLOGY ; ANOMALIES ; CHINA ; ENVIRONMENT ; POLLUTION ; EXPOSURE ; PROVINCE
资助项目NSFC[41401469] ; NSFC[81460282] ; NSFC[81260299] ; National Key Research and Development Program of China[2016YFC1000300] ; National Key Research and Development Program of China[2016YFC1000307] ; Qinghai Applied Basic Research Project[2017-ZJ-725] ; National Infrastructure of Chinese Genetic Resources[YCZYPT[2017]01-6]
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000431848500016
出版者ELSEVIER SCIENCE BV
资助机构NSFC ; National Key Research and Development Program of China ; Qinghai Applied Basic Research Project ; National Infrastructure of Chinese Genetic Resources
源URL[http://ir.igsnrr.ac.cn/handle/311030/54862]  
专题中国科学院地理科学与资源研究所
通讯作者Chen, Qiu-Hong; Ma, Xu; Wang, Bin-Bin
作者单位1.Natl Res Inst Family Planning, Beijing 100081, Peoples R China
2.Qinghai Cardiovasc Dis Vocat Hosp, Cent Lab, Xining 810012, Qinghai, Peoples R China
3.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China
4.Beijing GIStone Informat Technol Co Ltd, Beijing 100101, Peoples R China
5.Capital Med Univ, Sch Med Basic, Dept Med Genet & Dev Biol, Beijing 100069, Peoples R China
6.Peking Union Med Coll, Beijing 100730, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Li-Guang,Chen, Qiu-Hong,Wang, Yuan-Yuan,et al. Spatial pattern and variations in the prevalence of congenital heart disease in children aged 4-18 years in the Qinghai-Tibetan Plateau[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2018,627:158-165.
APA Ma, Li-Guang.,Chen, Qiu-Hong.,Wang, Yuan-Yuan.,Wang, Jing.,Ren, Zhou-Peng.,...&Wang, Bin-Bin.(2018).Spatial pattern and variations in the prevalence of congenital heart disease in children aged 4-18 years in the Qinghai-Tibetan Plateau.SCIENCE OF THE TOTAL ENVIRONMENT,627,158-165.
MLA Ma, Li-Guang,et al."Spatial pattern and variations in the prevalence of congenital heart disease in children aged 4-18 years in the Qinghai-Tibetan Plateau".SCIENCE OF THE TOTAL ENVIRONMENT 627(2018):158-165.

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来源：地理科学与资源研究所

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