中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism

文献类型:期刊论文

作者Zhao Jingjie1; Gao Xuesong2; Wang Anna2; Wang Yongzhi2; Du Yi2; Li Li2; Li Mingzhen1; Chong Li1,3; Jin Xiaoying1; Zhao Mei1,3
刊名Journal of Affective Disorders
出版日期2019
页码117-124
ISSN号0165-0327
关键词Pain Depression Chronic unpredictable mild stress Corticosterone Hypothalamic-pituitary-adrenal (HPA) axis Inflammation
产权排序1
文献子类Article
英文摘要

Background: Recent studies have indicated that inflammatory pathways and hypothalamic-pituitary-adrenal (HPA) axis function may be responsible for the interaction between pain and depression.

Methods: Animals were examined for depressive and painful behavior following exposure to chronic unpredictable mild stress (CUMS) and chronic corticosterone (CORT) treatment. Subsequently, serum cytokines, adrenocorticotropic hormone (ACTH) and CORT were measured by enzyme-linked immunosorbent assay (ELISA). mRNA expression of cytokines in the brain were measured by quantitative PCR (qPCR).

Results: The present study found that both CUMS and chronic CORT treatment induced behavioral changes of depression comorbid hyperalgesia. Moreover, both the treatments increased levels of serum ACTH, CORT, and cytokines including tumor necrosis factor alpha (TNFα), interleukin 1 beta (IL1ß), interleukin 6 (IL6), and Caspase 1 (CASP1). Following CUMS, Il1ß levels were found to be elevated in all examined regions, including the raphe nuclei, thalamus, hippocampus, prefrontal cortex, and pituitary. In the raphe nuclei particularly, CUMS elevated all examined cytokine levels. Chronic CORT treatment, however, produced Il1ß elevation in the hippocampus and the pituitary, with showing elevated levels in all examined cytokines.

Limitation: To clarify the causal relationship between behavioral changes and altered cytokine levels via either antidepressant treatment or blockage of pre-inflammatory cytokine production, further studies should be conducted.

语种英语
源URL[http://ir.psych.ac.cn/handle/311026/29141]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wang Yongzhi; Du Yi; Chong Li; Zhao Mei
作者单位1.CAS, Key Lab of Mental Health, Institute of Psychology
2.Beijing Friendship Hospital, Capital Medical University
3.University of Chinese Academy of Sciences
推荐引用方式
GB/T 7714
Zhao Jingjie,Gao Xuesong,Wang Anna,et al. Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism[J]. Journal of Affective Disorders,2019:117-124.
APA Zhao Jingjie.,Gao Xuesong.,Wang Anna.,Wang Yongzhi.,Du Yi.,...&Zhao Mei.(2019).Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism.Journal of Affective Disorders,117-124.
MLA Zhao Jingjie,et al."Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism".Journal of Affective Disorders (2019):117-124.

入库方式: OAI收割

来源:心理研究所

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