Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism
文献类型:期刊论文
作者 | Zhao Jingjie1; Gao Xuesong2; Wang Anna2; Wang Yongzhi2; Du Yi2; Li Li2; Li Mingzhen1; Chong Li1,3; Jin Xiaoying1; Zhao Mei1,3 |
刊名 | Journal of Affective Disorders |
出版日期 | 2019 |
页码 | 117-124 |
ISSN号 | 0165-0327 |
关键词 | Pain Depression Chronic unpredictable mild stress Corticosterone Hypothalamic-pituitary-adrenal (HPA) axis Inflammation |
产权排序 | 1 |
文献子类 | Article |
英文摘要 | Background: Recent studies have indicated that inflammatory pathways and hypothalamic-pituitary-adrenal (HPA) axis function may be responsible for the interaction between pain and depression. Methods: Animals were examined for depressive and painful behavior following exposure to chronic unpredictable mild stress (CUMS) and chronic corticosterone (CORT) treatment. Subsequently, serum cytokines, adrenocorticotropic hormone (ACTH) and CORT were measured by enzyme-linked immunosorbent assay (ELISA). mRNA expression of cytokines in the brain were measured by quantitative PCR (qPCR). Results: The present study found that both CUMS and chronic CORT treatment induced behavioral changes of depression comorbid hyperalgesia. Moreover, both the treatments increased levels of serum ACTH, CORT, and cytokines including tumor necrosis factor alpha (TNFα), interleukin 1 beta (IL1ß), interleukin 6 (IL6), and Caspase 1 (CASP1). Following CUMS, Il1ß levels were found to be elevated in all examined regions, including the raphe nuclei, thalamus, hippocampus, prefrontal cortex, and pituitary. In the raphe nuclei particularly, CUMS elevated all examined cytokine levels. Chronic CORT treatment, however, produced Il1ß elevation in the hippocampus and the pituitary, with showing elevated levels in all examined cytokines. Limitation: To clarify the causal relationship between behavioral changes and altered cytokine levels via either antidepressant treatment or blockage of pre-inflammatory cytokine production, further studies should be conducted. |
语种 | 英语 |
源URL | [http://ir.psych.ac.cn/handle/311026/29141] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Wang Yongzhi; Du Yi; Chong Li; Zhao Mei |
作者单位 | 1.CAS, Key Lab of Mental Health, Institute of Psychology 2.Beijing Friendship Hospital, Capital Medical University 3.University of Chinese Academy of Sciences |
推荐引用方式 GB/T 7714 | Zhao Jingjie,Gao Xuesong,Wang Anna,et al. Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism[J]. Journal of Affective Disorders,2019:117-124. |
APA | Zhao Jingjie.,Gao Xuesong.,Wang Anna.,Wang Yongzhi.,Du Yi.,...&Zhao Mei.(2019).Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism.Journal of Affective Disorders,117-124. |
MLA | Zhao Jingjie,et al."Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism".Journal of Affective Disorders (2019):117-124. |
入库方式: OAI收割
来源:心理研究所
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