Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia
文献类型：期刊论文
| 作者 | Xiu, Mei Hong1; Wang, Dong Mei2,3 ; Du, Xiang Dong4; Chen, Nan1; Tan, Shu Ping1; Tan, Yun Long1; Yang, Fu De1; Cho, Raymond Y.5; Zhang, Xiang Yang2,3
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| 刊名 | PSYCHONEUROENDOCRINOLOGY
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| 出版日期 | 2019-10-01 |
| 卷号 | 108页码:110-117 |
| ISSN号 | 0306-4530 |
| 关键词 | Schizophrenia BDNF Cytokine Interaction Executive function |
| DOI | 10.1016/j.psyneuen.2019.06.006 |
| 通讯作者 | Wang, Dong Mei(wangdm@psych.ac.cn) |
| 英文摘要 | Multiple lines of evidence indicate that patients with chronic schizophrenia (SCZ) display executive dysfunction across the illness course. However, the potential molecular pathophysiologic mechanisms remain poorly elucidated. Neurodevelopmental changes caused by alterations of inflammatory mediators and neurotrophins have been shown to occur in the earliest stages of SCZ, and be associated with executive dysfunction (ED) in SCZ. Therefore, the current study was to investigate whether the interplay between BDNF and inflammatory mediators was involved in the disruption of executive function of long-term hospitalized patients with chronic SCZ. Serum cytokines and BDNF levels were measured in 112 long-term hospitalized patients with chronic SCZ and 44 healthy normal controls. Executive functions were assessed by verbal fluency tests (VFT), the Stroop word-color test (Stroop), and the Wisconsin card sorting tests (WCST).The results showed that the patients had higher IL-2, IL-6, IL-8, but lower TNF-alpha and BDNF compared to control subjects. In the patient group, BDNF was positively associated with IL-2 and IL-8 levels, while lower BDNF levels were correlated with ED measured by VFT and WCST tests. Multiple stepwise regression analyses confirmed that BDNF x IL-8 and BDNF x TNF-alpha were factors influencing the total score of VFT, while BDNF x IL-8 and BDNF x TNF-alpha were recognized as influencing factors for WCST scores. Our results suggest complex interactions between BDNF and cytokines were involved in the pathophysiology of executive function impairments in patients with SCZ. |
| WOS关键词 | NEUROTROPHIC FACTOR ; INFLAMMATORY CYTOKINES ; DRUG-NAIVE ; COGNITIVE PERFORMANCE ; GENE-EXPRESSION ; METAANALYSIS ; MARKERS ; SERUM ; DISORDER ; DEFICITS |
| 资助项目 | CAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509] |
| WOS研究方向 | Endocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000484870800014 |
| 资助机构 | CAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China |
| 源URL | [http://ir.psych.ac.cn/handle/311026/29157]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Wang, Dong Mei |
| 作者单位 | 1.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Jiangsu Provinc, Peoples R China 5.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA |
| 推荐引用方式 GB/T 7714 | Xiu, Mei Hong,Wang, Dong Mei,Du, Xiang Dong,et al. Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia[J]. PSYCHONEUROENDOCRINOLOGY,2019,108:110-117. |
| APA | Xiu, Mei Hong.,Wang, Dong Mei.,Du, Xiang Dong.,Chen, Nan.,Tan, Shu Ping.,...&Zhang, Xiang Yang.(2019).Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia.PSYCHONEUROENDOCRINOLOGY,108,110-117. |
| MLA | Xiu, Mei Hong,et al."Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia".PSYCHONEUROENDOCRINOLOGY 108(2019):110-117. |
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来源：心理研究所
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